{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:35:43Z","timestamp":1745469343597,"version":"3.40.4"},"reference-count":12,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cytologica"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;i&gt;Objectives:&lt;\/i&gt; Robust evidence now supports human papillomavirus (HPV) testing as a more effective option to screening and as more sensitive than cytology in detecting high-grade cervical intraepithelial neoplasia . Our goal was to analyze the performance of the Hybrid Capture II (HC2) assay for high-risk HPV (hrHPV) in women undergoing gynecological examination at a public health hospital as part of the evaluation of HPV screening as an alternative or complement to cytology. &lt;i&gt;Study Design:&lt;\/i&gt; This analysis is a subset of a cross-sectional study carried out at a large public hospital serving a predominantly low-resource population. A total of 705 women were enrolled; the sensitivity and specificity of each test were estimated and compared. &lt;i&gt;Results:&lt;\/i&gt; The analysis identified 272 hrHPV-positive women (mean age 36.3 years) and 433 hrHPV-negative women (mean age 41.2 years). HPV testing showed a significantly increased sensitivity of the HC2 assay versus cytology (84.5 vs. 69.7%; p &lt; 0.0001) but a lower specificity (49.90 vs. 88.78%; p &lt; 0.0001). &lt;i&gt;Conclusion:&lt;\/i&gt; The combination of both methods seems to be useful in improving detection of cervical lesions.<\/jats:p>","DOI":"10.1159\/000335145","type":"journal-article","created":{"date-parts":[[2012,2,17]],"date-time":"2012-02-17T09:45:04Z","timestamp":1329471904000},"page":"160-165","source":"Crossref","is-referenced-by-count":2,"title":["Implementing Human Papillomavirus Testing in a Public Health Hospital: Challenges and Opportunities"],"prefix":"10.1159","volume":"56","author":[{"given":"Mariana Carmezim","family":"Beldi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maricy","family":"Tacla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helio","family":"Caiaffa-Filho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Ab\u2019saber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila","family":"Siqueira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmund Chada","family":"Baracat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venancio Avancini Ferreira","family":"Alves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adhemar","family":"Longatto-Filho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,2,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002%2Fijc.24525"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.vaccine.2008.06.019"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2807%2961450-0"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002%2Fijc.24010"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.a1754"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.b2968"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS1470-2045%2811%2970145-0"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.vaccine.2006.05.122"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136%2Fsti.2004.011858"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002%2Fijc.23489"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1186%2F1478-7547-4-13"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093%2Fjnci%2Fdjq562"}],"container-title":["Acta Cytologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/335145","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/335145","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:54:18Z","timestamp":1745434458000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000335145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":12,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,4,1]]},"published-print":{"date-parts":[[2012,3,7]]}},"URL":"https:\/\/doi.org\/10.1159\/000335145","archive":["Portico"],"relation":{},"ISSN":["0001-5547","1938-2650"],"issn-type":[{"type":"print","value":"0001-5547"},{"type":"electronic","value":"1938-2650"}],"subject":[],"published":{"date-parts":[[2012]]}}}