{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T08:19:45Z","timestamp":1789460385285,"version":"build-2803163510"},"reference-count":19,"publisher":"S. Karger AG","issue":"1-4","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurodegener Dis"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Normal pressure hydrocephalus (NPH) can be alleviated by cerebrospinal fluid shunting but the differential diagnosis and patient selection are challenging. Intraventricular intracranial pressure monitoring as part of the diagnostic workup as well as shunting enable to obtain cortical brain biopsies to detect amyloid-\u03b2 (A\u03b2) and hyperphosphorylated tau (HP\u03c4), the hallmark lesions of Alzheimer\u2019s disease (AD). In possible NPH, A\u03b2 alone indicates an increased risk of AD and when present with HP\u03c4 probable AD, but the effect of those brain lesions on survival is not known. The aim of this study was to evaluate the predictive value of brain biopsy for the long-term outcome of possible NPH. Between 1991 and 2006, the Neurosurgery Department of the Kuopio University Hospital evaluated 468 patients for possible NPH by intraventricular intracranial pressure monitoring and frontal cortical brain biopsy immunostained against A\u03b2 and HP\u03c4. All patients were followed up until the end of 2008 (n = 201) or death (n = 267) with a median follow-up of 4.6 years (range 0\u201317). Logistic regression analysis with Cox models was applied. Out of the 468 cases, A\u03b2 was detected in 197 (42%) cortical biopsies, and together with HP\u03c4 in 44 (9%). A\u03b2 alone indicated increased risk of AD and with HP\u03c4 probable AD, but it did not affect survival. Vascular aetiology was the most frequent cause of death. Cortical biopsy findings indicate that NPH is at present a heterogeneous syndrome and has notable overlapping with AD. Brain biopsy did not predict survival but may open a novel research window to study the pathobiology of neurodegeneration.<\/jats:p>","DOI":"10.1159\/000335155","type":"journal-article","created":{"date-parts":[[2012,2,13]],"date-time":"2012-02-13T08:17:56Z","timestamp":1329121076000},"page":"166-169","source":"Crossref","is-referenced-by-count":63,"title":["Cortical Brain Biopsy in Long-Term Prognostication of 468 Patients with Possible Normal Pressure Hydrocephalus"],"prefix":"10.1159","volume":"10","author":[{"given":"Ville","family":"Leinonen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M.","family":"Koivisto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Alafuzoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Okko T.","family":"Pyykk\u00f6","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaana","family":"Rummukainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"von und zu Fraunberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha E.","family":"J\u00e4\u00e4skel\u00e4inen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilkka","family":"Soininen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaakko","family":"Rinne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakari","family":"Savolainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2012,2,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.22100"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1227%2F01.neu.0000316271.90090.b9"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1080%2F02688690600852324"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007%2F978-3-211-85578-2_25"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1227%2F01.NEU.0000371972.74630.EC"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.21706"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097%2FJGP.0b013e3181a6516e"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00308809"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00401-006-0127-z"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093%2Fbrain%2Fawh543"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00401-010-0721-y"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.59.6.608"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.2006.095117"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.68.6.778"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.22015"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.65.10.noc80013"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007%2Fs007010050386"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2FS1474-4422%2810%2970223-4"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2FS0072-9752%2807%2901278-X"}],"container-title":["Neurodegenerative Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/335155","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/335155","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:54:21Z","timestamp":1745434461000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000335155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":19,"journal-issue":{"issue":"1-4","published-online":{"date-parts":[[2012,4,1]]},"published-print":{"date-parts":[[2012,4,19]]}},"URL":"https:\/\/doi.org\/10.1159\/000335155","archive":["Portico"],"relation":{},"ISSN":["1660-2854","1660-2862"],"issn-type":[{"value":"1660-2854","type":"print"},{"value":"1660-2862","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}