{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T09:25:33Z","timestamp":1750757133896,"version":"3.40.4"},"reference-count":36,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2012]]},"abstract":"<b><i>Background:<\/i><\/b> The aim of this study is to investigate the reciprocal effect of <i>Staphylococcus aureus<\/i> colonization and allergic rhinitis in an allergy model of mice. <b><i>Methods:<\/i><\/b> BALB\/c mice with intraperitoneal ovalbumin (OVA) sensitization and\/or intranasal <i>S. aureus<\/i> inoculation were prepared. The following 4 groups were designed: an OVA-sensitized <i>S. aureus<\/i>-inoculated (AR-SA) group, an OVA-sensitized uninoculated (AR) group, a nonsensitized <i>S. aureus<\/i>-inoculated (SA) group, and a nonsensitized uninoculated (control) group. After intranasal OVA challenge, nasal lavage fluid, peripheral blood, and nasal mucosa were collected. Polymorphonuclear cells in the nasal lavage fluid were counted, serum OVA-specific IgE and IgG1 were measured by enzyme immunoassays, and <i>IL-4<\/i>, <i>IL-5<\/i>, and <i>IFN-<\/i>\u03b3 <i>mRNAs<\/i> in the nasal mucosa were assessed by quantitative real-time reverse transcription-PCR. The number of <i>S. aureus<\/i> in the nasal mucosa and lavage fluid was counted. <b><i>Results:<\/i><\/b> Both eosinophil and neutrophil counts were larger in the AR-SA group than in the other groups. Both IgE and IgG1 levels were higher in the AR and AR-SA groups than in the SA and control groups, and the IgG1 level was higher in the AR-SA group than in the AR group. The expression of <i>IL-4 mRNA<\/i> was higher in the AR-SA group than in the other groups, and the expression of <i>IL-5 mRNA<\/i> was higher in the AR-SA group than in the SA group. The AR-SA group showed higher counts of <i>S. aureus<\/i> in the nasal mucosa than the SA group. <b><i>Conclusion:<\/i><\/b> These results indicate the mutually potentiating effect of <i>S. aureus<\/i> colonization and allergic rhinitis.<\/jats:p>","DOI":"10.1159\/000335200","type":"journal-article","created":{"date-parts":[[2012,5,3]],"date-time":"2012-05-03T08:12:56Z","timestamp":1336032776000},"page":"33-40","source":"Crossref","is-referenced-by-count":5,"title":["Synergism of <b><i>Staphylococcus aureus<\/i><\/b> Colonization and Allergic Reaction in the Nasal Cavity in Mice"],"prefix":"10.1159","volume":"159","author":[{"given":"Nobusuke","family":"Hohchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Hashida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-ichi","family":"Ohkubo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuro","family":"Wakasugi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takanori","family":"Mori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khac-Hung","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etsushi","family":"Kuroda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takako","family":"Ikeno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hatsumi","family":"Taniguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,5,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11882-003-0065-y"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1128%2FIAI.71.7.4206-4211.2003"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2222.2005.02195.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1067%2Fmai.2000.104256"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.2500%2F105065899781367500"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.2500%2F108854100778250905"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000076833"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159%2F000088868"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097%2F00005537-200410000-00027"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097%2F01.mlg.0000168111.11802.9c"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS1357-4310%2899%2901657-3"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093%2Fjac%2Fdkf506"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093%2Fclinids%2F23.6.1209"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jdermsci.2007.11.002"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1248%2Fbpb.28.1462"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2FS0091-6749%2896%2970100-8"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2F0091-6749%2894%2990076-0"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11882-006-0026-3"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2F0091-6749%2893%2990064-M"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2567.1998.00613.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.bjp.0706393"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1093%2Fintimm%2F11.2.243"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.coi.2010.01.012"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.172.3.921"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-3083.1989.tb01221.x"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.162.5.1726"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1159%2F000053587"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2222.2004.1954.x"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1146%2Fannurev.immunol.19.1.275"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.20061134"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ijmm.2007.11.006"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1067%2Fmai.2001.117455"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1128%2FIAI.74.4.2145-2153.2006"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.1994.tb00804.x"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1159%2F000275244"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11882-007-0054-7"}],"container-title":["International 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