{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:50:41Z","timestamp":1792176641162,"version":"4.4.0"},"reference-count":14,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Stereotact Funct Neurosurg"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Intracranial neoplasms can cause pain similar to trigeminal neuralgia. Literature regarding radiosurgery for this is limited. We present a retrospective review of patients with tumor-related facial pain from benign lesions treated with gamma knife radiosurgery (GKRS) at Wake Forest University. &lt;i&gt;Objectives: &lt;\/i&gt;The primary objectives were to determine long-term pain relief and predictive factors for pain alleviation. &lt;i&gt;Methods:&lt;\/i&gt; We reviewed 515 patients treated with GKRS for benign meningioma, vestibular schwannoma or trigeminal schwannoma between August 1999 and August 2010. Twenty-one eligible patients had tumor-related facial pain prior to GKRS. The median marginal tumor dose was 12 Gy. Long-term pain relief data were obtained by chart review and telephone interview. &lt;i&gt;Results:&lt;\/i&gt; The median follow-up for symptom evaluation was 3.8 years. Seventeen of 21 patients (81%) experienced a Barrow Neurological Institute (BNI) score of I\u2013III at 6 months following GKRS. Kaplan-Meier estimates of freedom from BNI IV\u2013V relapse were 66% at 1 year and 53% at 2 years. No pain relapses occurred after 2 years. &lt;i&gt;Conclusion:&lt;\/i&gt; GKRS of benign lesions is a noninvasive option for patients with tumor-related facial pain. Pain relief is modest, with the majority of pain relapses occurring within 2 years and approximately one half of patients maintaining relief beyond 2 years.<\/jats:p>","DOI":"10.1159\/000335873","type":"journal-article","created":{"date-parts":[[2012,4,18]],"date-time":"2012-04-18T07:46:27Z","timestamp":1334735187000},"page":"145-150","source":"Crossref","is-referenced-by-count":28,"title":["Gamma Knife Radiosurgery in the Treatment of Tumor-Related Facial Pain"],"prefix":"10.1159","volume":"90","author":[{"given":"Sarah E.","family":"Squire","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Michael","family":"Furr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothy A.","family":"Lowell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen B.","family":"Tatter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas L.","family":"Ellis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Daniel","family":"Bourland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan F.","family":"deGuzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Munley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth E.","family":"Ekstrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward G.","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin P.","family":"McMullen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2012,4,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3171%2Fjns.1986.64.6.0865"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00309988"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1227%2F01.neu.0000318187.10536.bf"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1227%2F01.NEU.0000311061.72626.0D"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ijrobp.2004.02.019"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ijrobp.2007.01.001"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3171%2Fjns.2007.106.1.18"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1227%2F01.NEU.0000341629.57676.DB"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11060-010-0173-1"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3171%2Fjns.2001.95.2.0199"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097%2F00006123-200003000-00010"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1227%2F01.NEU.0000088806.11659.D8"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3171%2F2009.7.JNS09694"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3171%2F2009.8.JNS081706"}],"container-title":["Stereotactic and Functional Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/335873","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/335873","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:01:33Z","timestamp":1745434893000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000335873"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":14,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,6,1]]},"published-print":{"date-parts":[[2012,6,20]]}},"URL":"https:\/\/doi.org\/10.1159\/000335873","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.5123221","asserted-by":"subject"}]},"ISSN":["1011-6125","1423-0372"],"issn-type":[{"value":"1011-6125","type":"print"},{"value":"1423-0372","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}