{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:51:40Z","timestamp":1787017900584,"version":"build-2736575974"},"reference-count":26,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmologica"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Aims:&lt;\/i&gt;&lt;\/b&gt; The objective of this study was to investigate the association between blood pressure (BP) and visual field defect progression in normal-tension glaucoma (NTG). &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; The subjects were 35 consecutive patients with NTG who were admitted to Keio University Hospital for 24-hour intraocular pressure evaluation; all subjects underwent 6 or more visual field tests in either eye and were followed up for more than 5 years. Systolic and diastolic BPs were measured at 9.00 h. Subjects with negative regression lines and p values of less than 0.05 were classified as progressive; all others were defined as stable. Systolic BP, diastolic BP, and ocular perfusion pressure were compared between the 2 groups. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Twelve subjects showed progression in glaucomatous visual field defects (age 55.1 \u00b1 15.1 years). Twenty-three subjects showed no progression (age 57.2 \u00b1 10.9 years). Diastolic BP (stable group: 77.0 \u00b1 12.1 mm Hg; progressive group: 67.7 \u00b1 9.7 mm Hg; p = 0.03) was significantly lower in the progressive group than in the stable group. Multivariable analysis revealed that low diastolic BP is a significant risk factor for progression (OR 0.90; 95% CI 0.82\u20130.99). &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Low diastolic BP was associated with glaucomatous visual field progression in subjects with NTG.<\/jats:p>","DOI":"10.1159\/000335978","type":"journal-article","created":{"date-parts":[[2012,2,28]],"date-time":"2012-02-28T09:03:46Z","timestamp":1330419826000},"page":"36-41","source":"Crossref","is-referenced-by-count":36,"title":["Low Diastolic Blood Pressure Is Associated with the Progression of Normal-Tension Glaucoma"],"prefix":"10.1159","volume":"228","author":[{"given":"Yoshihiko","family":"Okumura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenya","family":"Yuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Tsubota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2012,2,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.eye.6701973"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.survophthal.2008.08.006"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097%2FICU.0b013e3282f3919b"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136%2Fbjo.56.6.447"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0161-6420%2800%2900138-X"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1167%2Fiovs.03-0461"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001%2Farchopht.126.5.741-a"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136%2Fbjo.2008.149047"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097%2FICU.0b013e32831eef82"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1001%2Farchopht.1995.01100020100038"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1001%2Farchopht.1995.01100070092031"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ophtha.2007.03.017"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ajo.2006.02.055"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ophtha.2005.03.022"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10384-003-0071-6"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1001%2Farchopht.125.9.1176"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ajo.2010.01.018"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1001%2Farchopht.1973.01000040459003"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1136%2Fbjo.65.1.56"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00919280"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10384-006-0375-4"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ophtha.2007.03.016"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1167%2Fiovs.09-3716"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1136%2Fbjo.80.10.864"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1167%2Fiovs.06-0615"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.jhh.1001959"}],"container-title":["Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/335978","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/335978","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:02:56Z","timestamp":1745420576000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000335978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2012,6,1]]},"published-print":{"date-parts":[[2012,6,22]]}},"URL":"https:\/\/doi.org\/10.1159\/000335978","archive":["Portico"],"relation":{},"ISSN":["0030-3755","1423-0267"],"issn-type":[{"value":"0030-3755","type":"print"},{"value":"1423-0267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}