{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T08:41:25Z","timestamp":1761986485325,"version":"3.40.4"},"reference-count":21,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2012]]},"abstract":"Diagnosis of peanut allergy has improved thanks to component-resolved diagnostics. Peanut allergen component Ara h 2 is considered to indicate true peanut allergy. The component Ara h 6 is structurally similar to Ara h 2, but the diagnostic value of analyzing IgE antibodies to Ara h 6 is unclear. A boy sensitized (\u22650.35 kU<sub>A<\/sub>\/l) to Ara h 8 but not to Ara h 1, Ara h 2 and Ara h 3 was challenged with peanut and developed grade II anaphylaxis. In serum collected at the time of challenge a doubling of IgE to the peanut allergen extract was observed compared to allergy testing 9 months earlier. In contrast, IgE levels to Ara h 1, Ara h 2, Ara h 3 and to Ara h 8 were rather unchanged. After another 2 months, Ara h 6 was analyzed and revealed a level of 24 kU<sub>A<\/sub>\/l whilst Ara h 2 was 0.12 kU<sub>A<\/sub>\/l. We suggest that IgE sensitization to Ara h 6 caused the reaction and conclude that analyses of IgE levels to peanut and peanut components should be performed in connection with a challenge. Furthermore, levels to Ara h 2 below 0.35 kU<sub>A<\/sub>\/l may still indicate a risk of severe reaction at the time of challenge since in rare cases, Ara h 6 IgE antibodies may be present without occurrence of IgE antibodies to Ara h 2.<\/jats:p>","DOI":"10.1159\/000336027","type":"journal-article","created":{"date-parts":[[2014,12,8]],"date-time":"2014-12-08T15:04:18Z","timestamp":1418051058000},"page":"209-212","source":"Crossref","is-referenced-by-count":31,"title":["Anaphylaxis to Peanut in a Patient Predominantly Sensitized to Ara h 6"],"prefix":"10.1159","volume":"159","author":[{"given":"A.","family":"Asarnoj","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Glaumann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Elfstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Lilja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Lidholm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Nilsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Wickman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,6,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1067%2Fmai.2003.1551"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2009.10.008"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159%2F000321108"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2010.12.012"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1042%2FBJ20051728"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2004.09.014"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.2009.02138.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2222.2009.03312.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2009.06.008"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2010.09.010"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002%2Fmnfr.200400028"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2222.2005.02204.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2222.2009.03294.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002%2Fmnfr.201000011"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jim.2011.06.031"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1067%2Fmai.2002.125601"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2009.02.005"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2006.05.012"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.2011.02754.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2222.2010.03533.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2222.2002.01467.x"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/336027","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/336027","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:03:32Z","timestamp":1745435012000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000336027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":21,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,9,1]]},"published-print":{"date-parts":[[2012,9,17]]}},"URL":"https:\/\/doi.org\/10.1159\/000336027","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"type":"print","value":"1018-2438"},{"type":"electronic","value":"1423-0097"}],"subject":[],"published":{"date-parts":[[2012]]}}}