{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:32:57Z","timestamp":1790357577495,"version":"4.1.0"},"reference-count":24,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Objectives: Long-term durability of bioprosthetic heart valves (BPs) are limited by structural valve degeneration (SVD) leading to stenosis and\/or regurgitation. In this study, we sought to determine the metabolic markers associated with SVD. Methods: In a cohort of 220 patients with an aortic BP (mean follow-up of 2.5 \u00b1 1.2 years), we compared the metabolic and blood lipid profile including the levels of adiponectin and the proportion of small, dense low-density lipoprotein (LDL) particles (%LDL&lt;255\u00c5) in individuals developing echocardiographic evidence of early BP hemodynamic dysfunction with subjects having no features of BP dysfunction. Results: Patients developing BP dysfunction (n = 69; 31.3%) had a tendency of higher triglyceride levels. Moreover, patients with BP dysfunction had an increased proportion of %LDL&lt;255\u00c5. In multivariate linear regression analysis, after adjustment for age, gender, BP size and hypertension, the %LDL&lt;255\u00c5 (p = 0.04) was significantly associated with BP dysfunction. In addition, patients with an elevated level of %LDL&lt;255\u00c5 along with a decreased plasma adiponectin level were at a very high risk of developing early BP hemodynamic dysfunction (OR = 2.54, p = 0.04). Conclusion: BP dysfunction is significantly associated with an increased proportion of small, dense LDL.<\/jats:p>","DOI":"10.1159\/000336170","type":"journal-article","created":{"date-parts":[[2012,2,28]],"date-time":"2012-02-28T14:02:24Z","timestamp":1330437744000},"page":"20-26","source":"Crossref","is-referenced-by-count":14,"title":["Elevated Proportion of Small, Dense Low-Density Lipoprotein Particles and Lower Adiponectin Blood Levels Predict Early Structural Valve Degeneration of Bioprostheses"],"prefix":"10.1159","volume":"121","author":[{"given":"Rahul","family":"Shetty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Girerd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"C\u00f4t\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Arsenault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Despr\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Pibarot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Mathieu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2012,2,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-4636%2819991215%2947%3A4%3C439%3A%3AAID-JBM1%3E3.0.CO%3B2-O"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1161%2FCIRCULATIONAHA.105.549311"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-5223%2802%2973619-2"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-5223%2803%2900708-6"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1161%2FCIRCULATIONAHA.105.000422"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2362.2009.02132.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.amjcard.2003.08.066"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1161%2Fhc4401.098490"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.ijo.0800813"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1161%2FATVBAHA.107.154989"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093%2Feurheartj%2Fehm390"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159%2F000099097"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3349%2Fymj.2006.47.3.405"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS0828-282X%2808%2971043-2"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.82.2.495"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1161%2F01.ATV.14.6.902"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038%2F90992"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.2337%2Fdiabetes.52.9.2266"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000042707.50032.19"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.atherosclerosis.2008.04.011"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.2337%2Fdiabetes.50.9.2094"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1210%2Fen.143.3.998"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016%2F0021-9150%2894%2990108-2"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1161%2F01.ATV.16.6.763"}],"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/336170","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/crd\/article-pdf\/121\/1\/20\/3892916\/000336170.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/crd\/article-pdf\/121\/1\/20\/3892916\/000336170.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:05:02Z","timestamp":1745435102000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000336170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2012,3,1]]},"published-print":{"date-parts":[[2012,3,14]]}},"URL":"https:\/\/doi.org\/10.1159\/000336170","archive":["Portico"],"relation":{},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"value":"0008-6312","type":"print"},{"value":"1421-9751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}