{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T05:57:50Z","timestamp":1773381470158,"version":"3.50.1"},"reference-count":55,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; To evaluate biochemically and histopathologically the effects of &lt;i&gt;Nigella sativa&lt;\/i&gt; (NS) in experimental ischemia and ischemia\/reperfusion (I\/R) injury in rat ovaries. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Thirty-six female rats were divided into 6 groups: group I = sham operation; group II = 500 mg\/kg NS + sham operation; group III = bilateral ovarian ischemia; group IV = 500 mg\/kg NS + ischemia; group V = 3-hour period of ischemia + 3-hour reperfusion, and group VI: 3-hour period of ischemia + 500 mg\/kg NS 2.5 h after the induction of ischemia + 3-hour reperfusion. At the end of ischemia, the bilateral vascular clips were removed, and 3-hour reperfusion was continued. IL-1\u03b2, IL-6, and TNF-\u03b1 cytokine levels in serum, and superoxide dismutase (SOD), myeloperoxidase (MPO), glutathione (GSH), and malondialdehyde (MDA) levels were determined. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; I\/R increased the MDA level and MPO activity while significantly decreasing the SOD activity and GSH level when compared to the sham. The 500-mg\/kg dose of NS before I\/R reversed the trend in MDA levels, MPO activity, SOD activity, and GSH levels. Ischemia and I\/R increased the serum levels of IL-1\u03b2, IL-6, and TNF-\u03b1, while the administration of NS decreased the serum levels of these cytokines. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; The administration of NS is effective in reversing tissue damage induced by ischemia and\/or I\/R in ovaries.<\/jats:p>","DOI":"10.1159\/000336295","type":"journal-article","created":{"date-parts":[[2012,3,22]],"date-time":"2012-03-22T19:17:36Z","timestamp":1332443856000},"page":"41-49","source":"Crossref","is-referenced-by-count":28,"title":["&lt;b&gt;&lt;i&gt;Nigella Sativa&lt;\/i&gt;&lt;\/b&gt; Reduces Tissue Damage in Rat Ovaries Subjected to Torsion and Detorsion: Oxidative Stress, Proinflammatory Response and Histopathological 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