{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T15:22:03Z","timestamp":1783524123199,"version":"3.55.0"},"reference-count":14,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Peanut allergy is the leading cause of food-related anaphylaxis, and accidental exposures are common. Oral immunotherapy (OIT) has been posited as a potential treatment. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Patients aged 3\u201365 years with peanut-specific IgE \u22657 kU\/l and\/or a positive skin prick test with a history of an allergic reaction to peanut were recruited to undergo an OIT protocol. All adverse reactions were recorded by research staff or patients in real time. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Twenty-four patients received 6,662 doses. Symptoms were mostly mild (84%), and only 3 severe gastrointestinal reactions required the administration of epinephrine. Abdominal pain was the most common reaction, followed by oropharyngeal and lip pruritus. Respiratory symptoms were rare. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; In this trial of OIT in adults and children, most reactions were mild.<\/jats:p>","DOI":"10.1159\/000336391","type":"journal-article","created":{"date-parts":[[2012,8,28]],"date-time":"2012-08-28T07:42:29Z","timestamp":1346139749000},"page":"179-182","source":"Crossref","is-referenced-by-count":35,"title":["The Safety of Peanut Oral Immunotherapy in Peanut-Allergic Subjects in a Single-Center Trial"],"prefix":"10.1159","volume":"159","author":[{"given":"G.P.","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Weldon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Neale-May","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.C.","family":"Nadeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2012,6,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2010.11.044"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2006.12.622"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2010.10.040"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2009-1210"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2009.05.022"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2010.12.1111"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2010.04.030"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2009.03.045"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2010.05.012"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2010.08.053"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2010.08.052"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2010.08.051"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2F0091-6749%2888%2991021-4"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2010.10.008"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/336391","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/336391","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:06:19Z","timestamp":1745435179000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000336391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":14,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,9,1]]},"published-print":{"date-parts":[[2012,9,17]]}},"URL":"https:\/\/doi.org\/10.1159\/000336391","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}