{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:04:57Z","timestamp":1790881497427,"version":"4.1.0"},"reference-count":26,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2012]]},"abstract":"<b><i>Background:<\/i><\/b> The chronic obstructive pulmonary disease (COPD) assessment test (CAT) is a simple, self-completion questionnaire developed to measure health status in patients with COPD, which is potentially suitable for routine clinical use. <b><i>Objectives:<\/i><\/b> The purpose of this study was to establish the determinants of the CAT score in routine clinical practice. <b><i>Methods:<\/i><\/b> Patients attending the clinic completed the CAT score before being seen. Clinical data, including, where available, plethysmographic lung volumes, transfer factor and arterial blood gas analysis, were recorded on a pro forma in the clinic. <b><i>Results:<\/i><\/b> In 224 patients (36% female), mean forced expiratory volume in 1 s (FEV<sub>1<\/sub>) was 40.1% (17.9) of predicted (%pred); CAT score was associated with exacerbation frequency [0\u20131\/year 20.1 (7.6); 2\u20134\/year 23.5 (7.8); >4\/year 28.5 (7.3), p < 0.0001; 41\/40\/19% in each category] and with Medical Research Council (MRC) dyspnoea score (r<sup>2<\/sup> = 0.26, p < 0.0001) rising approximately 4 points with each grade. FEV<sub>1<\/sub> %pred had only a weak influence. Using stepwise regression, CAT score = 2.48 + 4.12 [MRC (1\u20135) dyspnoea score] + 0.08 (FEV<sub>1<\/sub> %pred) + 1.06 (exacerbation rate\/year)] (r<sup>2<\/sup> = 0.36, p < 0.0001). The CAT score was higher in patients (n = 54) with daily sputum production [25.9 (7.5) vs. 22.2 (8.2); p = 0.004]. Detailed lung function (plethysmography and gas transfer) was available in 151 patients but had little influence on the CAT score. <b><i>Conclusion:<\/i><\/b> The CAT score is associated with clinically important variables in patients with COPD and enables health status measurement to be performed in routine clinical practice.<\/jats:p>","DOI":"10.1159\/000336549","type":"journal-article","created":{"date-parts":[[2012,3,23]],"date-time":"2012-03-23T06:53:33Z","timestamp":1332485613000},"page":"193-199","source":"Crossref","is-referenced-by-count":78,"title":["Health Status Assessment in Routine Clinical Practice: The Chronic Obstructive Pulmonary Disease Assessment Test Score in Outpatients"],"prefix":"10.1159","volume":"84","author":[{"given":"Julia L.","family":"Kelly","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Bamsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cayley","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria M.","family":"Lord","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh","family":"Shrikrishna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul W.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael I.","family":"Polkey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas S.","family":"Hopkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2012,3,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0954-6111%2803%2980027-6"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1183%2F09031936.00102509"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.4104%2Fpcrj.2009.00053"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136%2Fthorax.56.11.880"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136%2Fthx.54.7.581"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1440-1843.2005.00718.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1136%2Fthx.2005.049940"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136%2Fthorax.57.10.847"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.129.3.536"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1164%2Frccm.200408-1054OC"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136%2Fthx.2003.008730"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1186%2F1465-9921-8-25"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.rmed.2006.07.010"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136%2Fthorax.58.7.589"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa0909883"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1183%2F09031936.00120107"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1186%2F1465-9921-11-63"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1164%2Frccm.200812-1873OC"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1164%2Frccm.200504-595OC"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1183%2F09031936.04.00113204"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa021322"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2809%2961301-5"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1164%2Frccm.200206-583OC"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.rmed.2010.03.001"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1136%2Fthx.2010.156372"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1183%2F09031936.00035909"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/336549","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/336549","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:07:19Z","timestamp":1745435239000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000336549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":26,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,8,1]]},"published-print":{"date-parts":[[2012,8,31]]}},"URL":"https:\/\/doi.org\/10.1159\/000336549","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}