{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T02:31:14Z","timestamp":1773887474148,"version":"3.50.1"},"reference-count":20,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Neurol"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; To clarify the change of systemic redox states in patients carrying the A3243G mutation in mitochondrial DNA (A3243G), we evaluated oxidative stress and antioxidant activity in the serum of patients. &lt;i&gt;Methods:&lt;\/i&gt; Oxidative stress and antioxidant activity in the serum samples obtained from 14 patients carrying A3243G and from 34 healthy controls were analyzed using the diacron-reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) tests, respectively. &lt;i&gt;Results:&lt;\/i&gt; The mean d-ROMs level of all patients was significantly greater than that of the controls (p &lt; 0.005), and the mean BAP\/d-ROMs ratio of all patients was significantly lower than that of the controls (p &lt; 0.02). In the patients with a history of stroke-like episodes (n = 10), both mean d-ROMs and BAP levels were increased compared with those of the controls (both p &lt; 0.01). The mean BAP level of the patients without a history of stroke-like episodes (n = 4) was significantly decreased compared with that of the controls (p &lt; 0.001), but the mean d-ROMs levels were not significantly different. &lt;i&gt;Conclusion:&lt;\/i&gt; d-ROMs and BAP tests indicated that patients carrying A3243G are always exposed to underlying oxidative stress, even at a remission state of stroke-like episodes.<\/jats:p>","DOI":"10.1159\/000336568","type":"journal-article","created":{"date-parts":[[2012,3,14]],"date-time":"2012-03-14T09:41:14Z","timestamp":1331718074000},"page":"232-237","source":"Crossref","is-referenced-by-count":18,"title":["Evaluation of Systemic Redox States in Patients Carrying the MELAS A3243G Mutation in Mitochondrial DNA"],"prefix":"10.1159","volume":"67","author":[{"given":"Masamichi","family":"Ikawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichiro","family":"Arakawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadanori","family":"Hamano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miwako","family":"Nagata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasunari","family":"Nakamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaru","family":"Kuriyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasutoshi","family":"Koga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Yoneda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,3,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038%2F348651a0"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.410160409"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136%2Fjmg.34.7.607"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-4598%28199702%2920%3A2%3C221%3A%3AAID-MUS13%3E3.0.CO%3B2-5"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038%2Fng0892-368"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2F0140-6736%2892%2992560-3"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0168-8227%2801%2900335-7"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.mito.2006.11.026"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.mito.2009.04.002"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.mito.2009.01.011"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1253%2Fcircj.69.617"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1006%2Fabio.1996.0292"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1515%2FCCLM.2002.019"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jns.2005.11.029"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jpeds.2007.02.016"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10157-007-0486-3"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.braindev.2008.10.008"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.96.9.4820"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2FS0891-5849%2887%2980033-3"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1163%2F156856700X00769"}],"container-title":["European Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/336568","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/336568","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/336568","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:07:36Z","timestamp":1745435256000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000336568"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":20,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2012,4,1]]},"published-print":{"date-parts":[[2012,4,20]]}},"URL":"https:\/\/doi.org\/10.1159\/000336568","archive":["Portico"],"relation":{},"ISSN":["0014-3022","1421-9913"],"issn-type":[{"value":"0014-3022","type":"print"},{"value":"1421-9913","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}