{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:37:48Z","timestamp":1770745068108,"version":"3.49.0"},"reference-count":33,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Aims:&lt;\/i&gt;&lt;\/b&gt; To investigate the frequency of and predictive factors for hypersensitivity reactions (HR) to taxanes and platinum salts in a cohort of patients treated for pelvic gynecologic malignancies. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; The medical records of all patients with gynecologic pelvic neoplasms treated with chemotherapy at the Department of Gynecologic Oncology, AO Mauriziano Umberto I of Turin, from September 2007 through August 2008, were retrospectively reviewed. Two multivariate models, regarding carboplatin and taxane chemotherapy, respectively, were performed to evaluate the potential predictive value of various clinical features. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The incidence of HR was 14% (22\/157). Multivariate models showed that menopausal women had a significantly lower probability of HR (OR 0.12, CI 0.02\u20131.13, p = 0.06 for the carboplatin model and OR 0.05, CI 0.01\u20130.63, p = 0.02 for the taxane model) while a history of systemic hypersensitivity was associated with a higher but non-significant risk of HR (OR 2.64, CI 0.78\u20138.95, p = 0.11, for the carboplatin model and OR 3.42, CI 0.94\u201312.45, p = 0.06, for the taxane model). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; We confirmed a history of hypersensitivity as a risk factor for HR. Other larger cohorts should be analyzed: we need to find new predictive factors in order to select women who should be submitted to experimental prophylactic strategies.<\/jats:p>","DOI":"10.1159\/000336772","type":"journal-article","created":{"date-parts":[[2012,5,31]],"date-time":"2012-05-31T07:23:52Z","timestamp":1338449032000},"page":"21-27","source":"Crossref","is-referenced-by-count":13,"title":["A Search for Predictive Factors for Hypersensitivity Reactions to Paclitaxel and Platinum Salts in Chemotherapy for Gynecologic Pelvic Neoplasms"],"prefix":"10.1159","volume":"74","author":[{"given":"E.","family":"Piovano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Pivetta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Modaffari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Martra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Baima Poma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Perotto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Tripodi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Zanfagnin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Zola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Ferrero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,5,31]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199504133321507"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2006.11.640"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093%2Fjnci%2Fdjg036"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2F0090-8258%2890%2990174-J"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199904153401503"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199904153401501"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2803%2913718-X"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199904153401502"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199904153401509"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097%2FCAD.0b013e32831961b3"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2003.05.539"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10549-010-1034-5"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2FIGC.0b013e3181c10513"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2006.10.4752"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00280-004-0924-9"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1186%2F1465-9921-11-115"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2FS0090-8258%2803%2900155-0"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ygyno.2006.04.002"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1159%2F000316348"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002%2Fppul.21065"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1399-3038.2008.00774.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.106.6.1406"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%2819950301%2975%3A5%3C1171%3A%3AAID-CNCR2820750518%3E3.0.CO%3B2-F"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016%2F0959-8049%2894%2990489-8"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1048-891x.2005.14401.x"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%2819940415%2973%3A8%3C2218%3A%3AAID-CNCR2820730830%3E3.0.CO%3B2-1"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016%2F0091-6749%2892%2990142-O"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1006%2Fgyno.2001.6519"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1006%2Fgyno.2001.6513"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1006%2Fgyno.1994.1098"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1525-1438.2005.00136.x"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1345%2Faph.10287"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1097%2F00130404-200605000-00013"}],"container-title":["Gynecologic and Obstetric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/336772","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/336772","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/336772","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:09:06Z","timestamp":1745435346000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000336772"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":33,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2012,7,1]]},"published-print":{"date-parts":[[2012,7,24]]}},"URL":"https:\/\/doi.org\/10.1159\/000336772","archive":["Portico"],"relation":{},"ISSN":["0378-7346","1423-002X"],"issn-type":[{"value":"0378-7346","type":"print"},{"value":"1423-002X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}