{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T11:44:53Z","timestamp":1771501493304,"version":"3.50.1"},"reference-count":28,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney Blood Press Res"],"published-print":{"date-parts":[[2012]]},"abstract":"Our previous studies in rats with ablation nephrectomy have shown similar cardiorenal protective effects of renin-angiotensin system (RAS)-dependent treatment (combination of angiotensin-converting enzyme inhibitor and angiotensin II receptor blocker) and RAS-independent treatment (combination of \u03b1- and \u03b2-adrenoreceptor antagonist and diuretics). Moreover, selective blockade of endothelin (ET) receptor type A (ET<sub>A<\/sub>) improved survival rate and attenuated hypertension and organ damage in Ren-2 transgenic rats. Therefore, we were interested in whether ET<sub>A<\/sub> receptor blockade could have additive effects to the classical blockade of the RAS. Transgenic rats underwent 5\/6 renal ablation at the age of 2 months and were treated for 20 weeks with RAS blockers alone (angiotensin II receptor blocker \u2013 losartan, and angiotensin-converting enzyme inhibitor \u2013 trandolapril), ET<sub>A<\/sub> receptor blocker alone (atrasentan) or with the combination of RAS and ET<sub>A<\/sub> receptor blockade. RAS blockade normalized blood pressure and improved survival. It decreased cardiac hypertrophy and proteinuria as well as tissue angiotensin II and ET-1 levels. In contrast, ET<sub>A<\/sub> receptor blockade only partially improved survival rate, reduced blood pressure, attenuated the development of cardiac hypertrophy and transiently reduced proteinuria. However, no additive cardio- and renoprotective effects of ET<sub>A<\/sub> and RAS blockade were noted at the end of the study.<\/jats:p>","DOI":"10.1159\/000336823","type":"journal-article","created":{"date-parts":[[2012,4,18]],"date-time":"2012-04-18T07:46:27Z","timestamp":1334735187000},"page":"382-392","source":"Crossref","is-referenced-by-count":28,"title":["Effects of Combined Endothelin A Receptor and Renin-Angiotensin System Blockade on the Course of End-Organ Damage in 5\/6 Nephrectomized Ren-2 Hypertensive 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