{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:42:13Z","timestamp":1791657733664,"version":"4.3.4"},"reference-count":9,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Neurosurg"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; Although rare, chronic hydrocephalus may cause amenorrhea and delayed puberty associated with obesity as the main endocrine manifestations. Since the first operation carried out in 1950 on a patient with amenorrhea and hydrocephalus, fewer than 30 patients with these features have been reported. &lt;b&gt;&lt;i&gt;Case Report:&lt;\/i&gt;&lt;\/b&gt; Our patient represents a teenage case of primary amenorrhea, partial adrenal insufficiency and adult growth hormone deficiency caused by hydrocephalus due to aqueductal stenosis. Our English-language literature search for similar well-documented cases yielded less than 30 cases. Our management consisted of endoscopic third ventriculostomy, which resulted in regular menstrual cycles and normalization of somato- and adrenocorticotropic axes. &lt;b&gt;&lt;i&gt;Discussion:&lt;\/i&gt;&lt;\/b&gt; This is a rare case of a 20-year-old woman with primary amenorrhea caused by hydrocephalus due to aqueductal stenosis. Neurosurgical treatment produced relief in hypothalamic hydrodynamics tension, allowing recovery of hormonal function and restoring normal menstrual cycles.<\/jats:p>","DOI":"10.1159\/000336880","type":"journal-article","created":{"date-parts":[[2012,4,26]],"date-time":"2012-04-26T09:17:56Z","timestamp":1335431876000},"page":"303-306","source":"Crossref","is-referenced-by-count":5,"title":["Hypopituitarism due to Hydrocephalus: Case Report and Review of the Literature"],"prefix":"10.1159","volume":"47","author":[{"given":"Fernando Campos Gomes","family":"Pinto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malebranche Berardo Carneiro","family":"da Cunha Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela Giuliani Marcondes","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Vicaria","family":"do Lago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello Delano","family":"Bronstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoel Jacobsen","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2012,5,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3171%2Fjns.1975.43.2.0239"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3171%2Fjns.1996.85.6.1148"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3109%2F09513598709030683"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0015-0282%2801%2901877-5"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0404.2005.00379.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.1.6170.1039"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.0954-6820.1981.tb11547.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11102-008-0142-2"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.1.6116.817"}],"container-title":["Pediatric Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/336880","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/336880","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:10:19Z","timestamp":1745435419000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000336880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":9,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2012,5,1]]},"published-print":{"date-parts":[[2012,5,8]]}},"URL":"https:\/\/doi.org\/10.1159\/000336880","archive":["Portico"],"relation":{},"ISSN":["1016-2291","1423-0305"],"issn-type":[{"value":"1016-2291","type":"print"},{"value":"1423-0305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}