{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:06:11Z","timestamp":1791907571052,"version":"4.3.4"},"reference-count":14,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Neuronal injury in pneumococcal meningitis is a consequence of microglial activation and direct toxicity by bacterial products and systemic inflammation. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; The treatment effect of the TEPC-15 antibody recognizing teichoic and lipoteichoic acids was investigated in murine microglial cells and in a rabbit model of pneumococcal meningitis. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; In vitro, the TEPC-15 antibody recognizing teichoic and lipoteichoic acids increased &lt;i&gt;Streptococcus pneumoniae&lt;\/i&gt; phagocytosis by murine microglial cells. In rabbit ceftriaxone-treated &lt;i&gt;S. pneumoniae&lt;\/i&gt; meningitis, intracisternal TEPC-15 reduced the density of apoptotic neurons in the hippocampal dentate gyrus (116 \u00b1 70 vs. 221 \u00b1 132\/mm&lt;sup&gt;2&lt;\/sup&gt;; p = 0.03). Cerebrospinal fluid inflammatory parameters (protein, lactate, leukocytes, prostaglandins) were not reduced in TEPC-15-treated rabbits. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Intracisternal treatment with the TEPC-15 antibody reduced neuronal damage probably by promoting rapid phagocytosis of bacterial products.<\/jats:p>","DOI":"10.1159\/000337287","type":"journal-article","created":{"date-parts":[[2012,7,3]],"date-time":"2012-07-03T15:29:28Z","timestamp":1341329368000},"page":"212-216","source":"Crossref","is-referenced-by-count":4,"title":["Intrathecal Treatment with the Anti-Phosphorylcholine Monoclonal Antibody TEPC-15 Decreases Neuronal Damage in Experimental Pneumococcal Meningitis"],"prefix":"10.1159","volume":"58","author":[{"given":"Joachim","family":"Gerber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Redlich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Ribes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone C.","family":"Tauber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Nau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2012,7,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0166-2236%2800%2902024-5"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI119084"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1128%2FIAI.01110-09"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093%2Finfdis%2F151.5.859"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1128%2FAAC.47.4.1313-1317.2003"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1086%2F314760"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097%2FCCM.0b013e3181a036c0"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1128%2FAAC.00812-09"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1128%2FAAC.01014-06"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159%2F000330855"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159%2F000223069"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0165-5728%2800%2900402-1"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI200212035"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2F0006-8993%2885%2991383-6"}],"container-title":["Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/337287","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/337287","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/337287","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:13:51Z","timestamp":1745435631000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000337287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":14,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,8,1]]},"published-print":{"date-parts":[[2012,8,24]]}},"URL":"https:\/\/doi.org\/10.1159\/000337287","archive":["Portico"],"relation":{},"ISSN":["0009-3157","1421-9794"],"issn-type":[{"value":"0009-3157","type":"print"},{"value":"1421-9794","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}