{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T15:56:37Z","timestamp":1760975797851,"version":"3.40.4"},"reference-count":31,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2012,5,8]],"date-time":"2012-05-08T00:00:00Z","timestamp":1336435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,5,8]],"date-time":"2012-05-08T00:00:00Z","timestamp":1336435200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurodegener Dis"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; An accurate diagnosis is important for timely and adequate treatment in patients with clinically uncertain parkinsonian syndrome (CUPS). &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; The objective of this study was to assess safety and changes in clinical management, diagnosis and quality of life (QoL) at 4 and 12 weeks following DaTscan\u2122 (ioflupane [&lt;sup&gt;123&lt;\/sup&gt;I] injection) imaging in patients with CUPS. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; This randomized, open-label, single-dose, multicenter trial was carried out in patients with CUPS who were randomized to either a DaTscan imaging group or to a control group without imaging. The main outcome measures were the proportions of patients with changes in clinical management and diagnosis from baseline through to 12 weeks after DaTscan. A total of 19 university hospital centers in Europe and the USA participated in the study. There were 267 patients enrolled and randomized (131 DaTscan, 136 control). &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Significantly more DaTscan patients had changes in clinical management after 12 weeks (p = 0.004) compared to the control group, and significantly more DaTscan patients had changes in diagnosis at 4 weeks and at 12 weeks (both p &lt; 0.001) compared to control patients. No significant difference in total score for QoL was observed between groups during the study duration. DaTscan was safe and well-tolerated. No deaths, serious adverse events (AEs) or withdrawals due to AEs occurred during the study. One patient had a headache following treatment with a suspected relationship to DaTscan. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; DaTscan imaging significantly affected the clinical management and diagnosis of patients with CUPS. DaTscan is safe and well-tolerated and is a useful adjunct to differential diagnosis of CUPS.<\/jats:p>","DOI":"10.1159\/000337351","type":"journal-article","created":{"date-parts":[[2012,5,8]],"date-time":"2012-05-08T09:51:19Z","timestamp":1336470679000},"page":"22-32","source":"Crossref","is-referenced-by-count":13,"title":["Changes in Clinical Management and Diagnosis following DaTscan\u2122 SPECT Imaging in Patients with Clinically Uncertain Parkinsonian Syndromes: A 12-Week Follow-Up Study"],"prefix":"10.1159","volume":"11","author":[{"given":"Andreas","family":"Kupsch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nin","family":"Bajaj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederick","family":"Weiland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Tartaglione","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Klutmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald","family":"Copp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Sherwin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Tate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor D.","family":"Grachev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,5,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0072-9752%2807%2983006-5"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2Fmds.10305"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.1993.00540020018011"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.51.6.745"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00415-006-4002-6"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002%2Fmds.21685"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02260863"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093%2Fageing%2F28.2.99"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002%2Fmds.10592"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.61.8.1224"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002%2Fmds.10010"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002%2F1531-8257%28200005%2915%3A3%3C503%3A%3AAID-MDS1013%3E3.0.CO%3B2-V"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00702-004-0208-x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1021%2Fjm00037a004"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007%2Fs002590000460"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002%2Fmds.20112"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002%2Fmds.21710"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159%2F000137111"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.69.1.67"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00259-002-0938-7"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.2009.193391"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1097%2F00005072-199111000-00006"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.2005.081711"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1212%2FWNL.43.4.829"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002%2Fmds.23019"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00259-008-0777-2"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00702-005-0401-6"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.parkreldis.2004.12.005"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.2165%2F00019053-200119070-00003"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1002%2F1531-8257%28200011%2915%3A6%3C1112%3A%3AAID-MDS1008%3E3.0.CO%3B2-A"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jocn.2008.01.020"}],"container-title":["Neurodegenerative Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/337351","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/337351","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:14:49Z","timestamp":1745435689000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000337351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,8]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2012,9,1]]},"published-print":{"date-parts":[[2012,9,11]]}},"URL":"https:\/\/doi.org\/10.1159\/000337351","archive":["Portico"],"relation":{},"ISSN":["1660-2854","1660-2862"],"issn-type":[{"type":"print","value":"1660-2854"},{"type":"electronic","value":"1660-2862"}],"subject":[],"published":{"date-parts":[[2012,5,8]]}}}