{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T18:29:06Z","timestamp":1779042546137,"version":"3.51.4"},"reference-count":10,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Princ Pract"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; To determine the potential antiulcer activity of methanol extract of &lt;i&gt;Melastoma malabathricum&lt;\/i&gt; leaves (MEMM) using various established rat models. &lt;b&gt;&lt;i&gt;Materials and Methods:&lt;\/i&gt;&lt;\/b&gt; Ten groups of rats were used and orally administered 10% DMSO (negative control), 100 mg\/kg ranitidine (positive control) or MEMM (50, 250 and 500 mg\/kg) followed by gastric ulcer induction either using ethanol or indomethacin. The stomachs were collected and subjected to macroscopic and microscopic analyses. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; MEMM exhibited significant (p &lt; 0.05) antiulcer activity in the ethanol, but not in the indomethacin-induced gastric ulcer model. The percentage of antiulcer activity for 50\u2013500 mg\/kg MEMM ranged between 3 and 75%, respectively. The gross observations were supported by histological findings. MEMM also aggravated the indomethacin-induced gastric ulcer, leading to an increase in ulcer area formation and ulcer score. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; The &lt;i&gt;M. malabathricum&lt;\/i&gt; leaves showed antiulcer activity, which could be attributed to their antioxidant and anti-inflammatory activities. This requires further in-depth studies.<\/jats:p>","DOI":"10.1159\/000337406","type":"journal-article","created":{"date-parts":[[2012,4,20]],"date-time":"2012-04-20T07:26:24Z","timestamp":1334906784000},"page":"501-503","source":"Crossref","is-referenced-by-count":16,"title":["Antiulcer Activity of Methanol Extract of &lt;b&gt;&lt;i&gt;Melastoma malabathricum&lt;\/i&gt;&lt;\/b&gt; Leaves in Rats"],"prefix":"10.1159","volume":"21","author":[{"given":"Z.","family":"Zabidi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.N.","family":"Wan Zainulddin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.S.","family":"Mamat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Shamsahal Din","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.H.","family":"Kamisan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Yahya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.A.","family":"Ismail","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Rodzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Mohtarrudin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.N.","family":"Somchit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.A.","family":"Zakaria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,4,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3742%2FOPEM.2010.10.3.222"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0378-8741%2898%2900126-3"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3844%2Fajptsp.2009.89.93"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1155%2F2012%2F258434"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jep.2011.07.038"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jep.2010.10.008"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jams.2011.09.016"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002%2Fptr.2650080313"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0031-9422%2899%2900198-3"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002%2Fptr.2011"}],"container-title":["Medical Principles and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/337406","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/337406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:15:08Z","timestamp":1745435708000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000337406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":10,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2012,7,1]]},"published-print":{"date-parts":[[2012,7,31]]}},"URL":"https:\/\/doi.org\/10.1159\/000337406","archive":["Portico"],"relation":{},"ISSN":["1011-7571","1423-0151"],"issn-type":[{"value":"1011-7571","type":"print"},{"value":"1423-0151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}