{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T01:39:03Z","timestamp":1789004343607,"version":"build-2803163510"},"reference-count":18,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Dapsone has potent anti-inflammatory effects and remains an effective therapy in a variety of skin disorders: cutaneous vasculitis, neutrophilic dermatoses and blistering disorders. However it may cause a severe idiosyncratic reaction compatible with drug-induced DRESS (drug reaction with eosinophilia and systemic symptoms) leading to the discontinuation of the treatment despite its effectiveness. We report a 68-year-old woman who was successfully treated with dapsone for erythema elevatum diutinum. However she developed a hypersensitivity syndrome compatible with DRESS with fever, skin rash and acute hepatitis confirmed in vitro by the presence of circulating dapsone-specific T cells. Dapsone therapy was suspended, leading to a relapse of erythema elevatum diutinum. While alternative therapies were totally ineffective in our patient to improve her skin condition, we proposed a tolerance induction protocol to dapsone with excellent results.<\/jats:p>","DOI":"10.1159\/000337424","type":"journal-article","created":{"date-parts":[[2012,4,17]],"date-time":"2012-04-17T14:26:03Z","timestamp":1334672763000},"page":"115-119","source":"Crossref","is-referenced-by-count":8,"title":["Alternative Procedure to Allow Continuation of Dapsone Therapy despite Serious Adverse Reaction in a Case of Dapsone-Sensitive Erythema Elevatum Diutinum"],"prefix":"10.1159","volume":"224","author":[{"given":"Julien","family":"Seneschal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Guillet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Ezzedine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Ta\u00efeb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Milpied","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2012,4,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2F0190-9622%2892%2970003-X"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2133.2000.03673.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0190-9622%2896%2990667-2"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.2008.01674.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1600-0536.2001.450601.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1398-9995.2000.00622.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1017%2FS1462399402004763"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1067%2Fmjd.2001.114733"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1186%2F1745-6673-1-9"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.amjmed.2011.01.017"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2006.07704.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2007.07807.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.1981.01650010044023"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.2004.00547.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159%2F000290775"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.annder.2009.06.021"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.annder.2010.04.024"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-4632.2010.04593.x"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/337424","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/337424","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:15:12Z","timestamp":1745435712000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000337424"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":18,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,5,1]]},"published-print":{"date-parts":[[2012,5,31]]}},"URL":"https:\/\/doi.org\/10.1159\/000337424","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}