{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:36:48Z","timestamp":1745469408500,"version":"3.40.4"},"reference-count":6,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cytologica"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; It was the aim of this study to evaluate the significance of reporting hyperkeratosis in cervical smears. &lt;b&gt;&lt;i&gt;Study Design:&lt;\/i&gt;&lt;\/b&gt; Cervicovaginal smears with low-grade (LSIL) and high-grade squamous intraepithelial lesions (HSIL), prepared from 2004 to 2007, were retrospectively reviewed. Anucleated squamous cells were counted. The smears were classified into two groups, based on the presence of &lt;2 or \u22652 clusters of anucleated cells, and then compared. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Sixty Pap smears showing SILs (34 LSILs and 26 HSILs) as well as 120 random satisfactory smears without squamous or glandular abnormalities were selected. A statistically significant difference was found between the SIL group and the control group regarding the mean number of hyperkeratotic clusters (2.8 in the SIL and 1.9 in the control group; p = 0.012). Moreover, the mean number of hyperkeratotic clusters (3.3 in the LSIL and 2.2 in the HSIL group) had a statistically significant correlation with the diagnosis of the lesion as LSIL or HSIL (p = 0.0006). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Our findings suggest that hyperkeratosis in the form of \u22652 clusters of anucleated squamous cells could be an indicator of underlying LSIL.<\/jats:p>","DOI":"10.1159\/000337453","type":"journal-article","created":{"date-parts":[[2012,7,25]],"date-time":"2012-07-25T08:18:20Z","timestamp":1343204300000},"page":"379-382","source":"Crossref","is-referenced-by-count":2,"title":["The Significance of Hyperkeratosis in Pap Smears with Squamous Intraepithelial Lesion"],"prefix":"10.1159","volume":"56","author":[{"given":"Narges","family":"Izadi-Mood","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soheila","family":"Sarmadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sorour","family":"Alijani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Sanii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,7,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093%2Fjnci%2Fdjn444"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111%2FIGC.0b013e3181cd184c"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ogc.2007.09.004"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1067%2Fmob.2002.126640"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0339%28199712%2917%3A6%3C447%3A%3AAID-DC13%3E3.0.CO%3B2-M"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1479-828X.2009.00998.x"}],"container-title":["Acta Cytologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/337453","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/337453","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:15:19Z","timestamp":1745435719000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000337453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":6,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2012,8,1]]},"published-print":{"date-parts":[[2012,8,29]]}},"URL":"https:\/\/doi.org\/10.1159\/000337453","archive":["Portico"],"relation":{},"ISSN":["0001-5547","1938-2650"],"issn-type":[{"type":"print","value":"0001-5547"},{"type":"electronic","value":"1938-2650"}],"subject":[],"published":{"date-parts":[[2012]]}}}