{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:32:25Z","timestamp":1761708745114,"version":"3.40.4"},"reference-count":29,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Pityriasis rubra pilaris (PRP) includes a spectrum of rare chronic inflammatory disorders with papulosquamous eruptions of unknown cause. Different etiologies have been proposed such as vitamin A metabolism dysfunction, association with autoimmune disorders, infection or malignancies. However, PRP seems to be a polygenic skin disorder. Classical systemic treatment is empirical and includes retinoids and methotrexate; however, only few series on treatments exist. Recently there has been an increasing number of reports documenting that new biologicals and in particular TNF-\u03b1 blockers are safe and effective.<\/jats:p>","DOI":"10.1159\/000337546","type":"journal-article","created":{"date-parts":[[2012,4,17]],"date-time":"2012-04-17T14:26:03Z","timestamp":1334672763000},"page":"120-125","source":"Crossref","is-referenced-by-count":20,"title":["Pityriasis Rubra Pilaris: Treatment with Biologics \u2013 A New Promising Therapy?"],"prefix":"10.1159","volume":"224","author":[{"given":"Katja","family":"Ivanova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Itin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Haeusermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,4,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0190-9622%2808%2980543-9"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.1933.01460050094008"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.1981.tb00946.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1525-1470.2002.00236_5.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159%2F000246871"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159%2F000240018"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2011.10639.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.1995.tb06939.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097%2F00000372-198608000-00001"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1440-0960.1997.tb01099.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.1968.01610160013003"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.1982.tb00525.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159%2F000251169"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.1995.01690160076012"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.1980.01640320038010"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2FS0190-9622%2882%2980258-2"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-4362.1999.00513.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1525-1470.2001.01967.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2008.05.037"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10227-002-0134-1"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1440-0960.2006.00247.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.2340%2F00015555-0308"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.141.4.423"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1468-3083.2009.03511.x"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1159%2F000102039"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.143.10.1252"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1001%2Farchdermatol.2008.527"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2230.2010.03806.x"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1529-8019.2011.01404.x"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/337546","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/337546","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:15:41Z","timestamp":1745435741000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000337546"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":29,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,5,1]]},"published-print":{"date-parts":[[2012,5,31]]}},"URL":"https:\/\/doi.org\/10.1159\/000337546","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"type":"print","value":"1018-8665"},{"type":"electronic","value":"1421-9832"}],"subject":[],"published":{"date-parts":[[2012]]}}}