{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T01:51:21Z","timestamp":1791165081809,"version":"4.1.0"},"reference-count":16,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Neurol"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; Huntington\u2019s disease (HD) is an autosomal dominant neurodegenerative disorder characterized by involuntary movements and psychiatric disturbances, found worldwide, with a variable prevalence. The purpose of this study was to determine the history of HD in Iceland and determine the prevalence and incidence of HD. &lt;b&gt;&lt;i&gt;Materials and Methods:&lt;\/i&gt;&lt;\/b&gt; Clinical information was obtained from general, neurologic, and psychiatric hospitals, practicing neurologists, general practitioners, and family members of affected individuals. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Twenty-seven individuals were identified with typical symptoms of HD from the 1850s to 2007. All but one sporadic case are descendants of a husband and wife living in the early and mid-19th century. The point prevalence of HD in Iceland is 1.0 per 100,000 individuals. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; The prevalence of HD in Iceland is markedly lower than in the neighboring countries (Norway and the British Isles), where Icelanders originate from.<\/jats:p>","DOI":"10.1159\/000337680","type":"journal-article","created":{"date-parts":[[2012,6,20]],"date-time":"2012-06-20T10:39:14Z","timestamp":1340188754000},"page":"48-51","source":"Crossref","is-referenced-by-count":19,"title":["An Unusually Low Prevalence of Huntington\u2019s Disease in Iceland"],"prefix":"10.1159","volume":"68","author":[{"given":"\u00d3lafur","family":"Sveinsson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigur\u00f0ur","family":"Halld\u00f3rsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias","family":"Olafsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2012,6,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2887%2992545-1"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00194305"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0404.1969.tb01225.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1086%2F302816"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1017%2FS0033291700002518"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0447.1974.tb08909.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1192%2Fbjp.155.6.799"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.1.5288.1301"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1399-0004.1981.tb00701.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS1569-1993%2806%2980392-9"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.1150232"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002%2Fgepi.1370030606"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.1988.00520320068017"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1212%2FWNL.10.2.148"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136%2Fjmg.29.12.911"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002%2Fajmg.a.32901"}],"container-title":["European Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/337680","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/337680","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/337680","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:13:15Z","timestamp":1745431995000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000337680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2012,7,1]]},"published-print":{"date-parts":[[2012,7,20]]}},"URL":"https:\/\/doi.org\/10.1159\/000337680","archive":["Portico"],"relation":{},"ISSN":["0014-3022","1421-9913"],"issn-type":[{"value":"0014-3022","type":"print"},{"value":"1421-9913","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}