{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T11:00:19Z","timestamp":1770289219865,"version":"3.49.0"},"reference-count":28,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Chorioamnionitis is a major risk factor for preterm birth in multifetal pregnancies. However, there is little clinical data whether chorioamnionitis is restricted to one amniotic compartment in multifetal pregnancies. &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; To explore whether chorioamnionitis is confined to the exposed compartment and does not cross to the unaffected fetus in twin pregnancy. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; In twin pregnant sheep, one of the twins was exposed to either 2 or 14 days of intra-amniotic lipopolysaccharide (LPS) while the co-twin was exposed to either 2 or 14 days of intra-amniotic saline (n = 3 for each exposure). Singletons were included in this study to compare the grade of inflammation with twins. All fetuses were delivered at 125 days of gestation (term = 150 days). Chorioamnionitis was confirmed by histological examination. Lung inflammation was assessed by cell count in bronchoalveolar lavage. Lung compliance was assessed at 40 cm H&lt;sub&gt;2&lt;\/sub&gt;O. Results were compared using analysis of variance (ANOVA) with a post-hoc Tukey analysis. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Inflammation in placenta, membranes and lung of LPS-exposed twins was significantly higher after 2 and 14 days of exposure when compared to the saline-exposed co-twins. Lung compliance in LPS-exposed twins was significantly increased after 14 days when compared to saline-exposed co-twins. Intrauterine LPS exposure increased lung compliance and inflammation in the membranes, placenta and lung to the same extent in twins as in singletons. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; In twin pregnant sheep, inflammation of the membranes, placenta and fetal lung was strictly limited to the exposed fetus in the amniotic compartment in which the LPS was injected.<\/jats:p>","DOI":"10.1159\/000338015","type":"journal-article","created":{"date-parts":[[2012,5,21]],"date-time":"2012-05-21T13:11:18Z","timestamp":1337605878000},"page":"81-88","source":"Crossref","is-referenced-by-count":7,"title":["Lipopolysaccharide-Induced Chorioamnionitis Is Confined to One Amniotic Compartment in Twin Pregnant Sheep"],"prefix":"10.1159","volume":"102","author":[{"given":"Markus","family":"Gantert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reint K.","family":"Jellema","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heike","family":"Heineman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Gantert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer J.P.","family":"Collins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Seehase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Verena A.C.","family":"Lambermont","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Keck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Garnier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc J.I.","family":"Zimmermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmed","family":"Kadyrov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.W. Danilo","family":"Gavilanes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris W.","family":"Kramer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,5,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2808%2960074-4"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2006-1070"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1080%2F080352501300067532"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2005-2522"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jpedsurg.2009.02.013"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2805%2982418-7"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2808%2960136-1"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097%2FGRF.0b013e31811ebef6"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159%2F000320170"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038%2Fjp.2010.96"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3109%2F00016349609054686"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0301-2115%2899%2900297-3"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2007-993962"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10024-003-7070-y"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159%2F000326620"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ajog.2007.05.044"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2FS0301-2115%2897%2900111-5"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ajog.2008.08.046"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1067%2Fmob.2000.107319"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2FS0301-2115%2802%2900430-X"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ajog.2004.07.055"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-0030-1262513"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ejogrb.2004.11.036"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ajog.2004.03.002"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1097%2F01.AOG.0000103995.79536.9C"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1038%2Flabinvest.2009.49"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9378%2803%2900810-X"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1152%2Fajplung.00389.2004"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/338015","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/338015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:15:59Z","timestamp":1745432159000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000338015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":28,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,8,1]]},"published-print":{"date-parts":[[2012,8,8]]}},"URL":"https:\/\/doi.org\/10.1159\/000338015","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}