{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T04:05:38Z","timestamp":1759032338689,"version":"3.40.4"},"reference-count":55,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells Tissues Organs"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; Previously, we introduced the biogenic conduit (BC) as a novel autologous nerve conduit for bridging peripheral nerve defects and tested its regenerative capacity in a short- and long-term setting. The aim of the present study was to clarify whether intraluminal application of regeneration-promoting glial cells, including Schwann cells (SC) and olfactory ensheathing cells (OEC), displayed differential effects after sciatic nerve gap bridging. &lt;b&gt;&lt;i&gt;Material and Methods:&lt;\/i&gt;&lt;\/b&gt; BCs were generated as previously described. The conduits filled with fibrin\/SC (n = 8) and fibrin\/OEC (n = 8) were compared to autologous nerve transplants (NT; n = 8) in the 15-mm sciatic nerve gap lesion model of the rat. The sciatic functional index was evaluated every 4 weeks. After 16 weeks, histological evaluation followed regarding nerve area, axon number, myelination index and N ratio. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Common to all groups was a continual improvement in motor function during the observation period. Recovery was significantly better after SC transplantation compared to OEC (p &lt; 0.01). Both cell transplantation groups showed significantly worse function than the NT group (p &lt; 0.01). Whereas nerve area and axon number were correlated to function, being significantly lowest in the OEC group (p &lt; 0.001), both cell groups showed lowered myelination (p &lt; 0.001) and lower N ratio compared to the NT group. &lt;b&gt;&lt;i&gt;Discussion:&lt;\/i&gt;&lt;\/b&gt; SC-filled BCs led to improved regeneration compared to OEC-filled BCs in a 15-mm-long nerve gap model of the rat.<\/jats:p>","DOI":"10.1159\/000338059","type":"journal-article","created":{"date-parts":[[2012,6,14]],"date-time":"2012-06-14T13:52:37Z","timestamp":1339681957000},"page":"534-542","source":"Crossref","is-referenced-by-count":15,"title":["Comparison of Schwann Cells and Olfactory Ensheathing Cells for Peripheral Nerve Gap Bridging"],"prefix":"10.1159","volume":"196","author":[{"given":"Vincenzo","family":"Penna","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.-Bjoern","family":"Stark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantin","family":"Wewetzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Radtke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva M.","family":"Lang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,6,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2F0896-6273%2891%2990265-2"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2990.1997.tb01313.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.expneurol.2010.08.028"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1089%2F107632701300003287"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291098-2752%282000%2920%3A1%3C37%3A%3AAID-MICR7%3E3.0.CO%3B2-5"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1179%2F016164104225013798"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2007-1006587"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1096%2Ffj.04-2833rev"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00418-011-0796-0"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2F0006-8993%2879%2990048-9"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1089%2F107632700320757"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00939235"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2F0006-8993%2892%2991182-E"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1089%2F107632701753213147"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0896-6273%2800%2900080-5"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002%2Fglia.20697"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2F0896-6273%2892%2990168-D"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097%2F00006123-199904000-00077"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002%2Fmus.21907"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1371%2Fjournal.pone.0022816"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1006%2Fexnr.2001.7774"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2FS0007-1226%2897%2991325-4"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1469-7580.2000.19740591.x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3171%2FFOC.2009.26.2.E4"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016%2FS0963-6897%2898%2900005-0"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016%2FS0006-8993%2899%2902285-4"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bjps.2007.12.015"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.3171%2Fjns.1994.80.2.0254"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1002%2F1098-1136%28200012%2932%3A3%3C214%3A%3AAID-GLIA20%3E3.0.CO%3B2-7"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1089%2Ften.tea.2010.0514"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2007-1006810"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1097%2FSAP.0b013e31804d441c"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1083%2Fjcb.119.1.45"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1002%2Fmicr.20894"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.brainres.2008.11.036"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1016%2FS0074-7742%2809%2987022-0"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1399-3089.2009.00562.x"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neulet.2008.07.097"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.3727%2F096368910X522081"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1016%2FS0361-9230%2897%2900463-2"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1002%2Fglia.440050105"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.expneurol.2011.03.001"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1523%2FJNEUROSCI.1998-04.2004"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1016%2F0303-8467%2893%2990040-N"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.3171%2Fjns.2005.103.6.1067"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1002%2Fglia.1121"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2007-1006407"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1002%2Fmicr.10147"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1097%2F00001756-199904060-00035"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1017%2FS1740925X06000305"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1016%2FS0304-3940%2801%2901891-2"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1016%2F0022-1759%2896%2900018-X"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.expneurol.2010.08.029"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00441-002-0607-y"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1016%2FS0169-328X%2801%2900044-4"}],"container-title":["Cells Tissues Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/338059","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/338059","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:16:10Z","timestamp":1745432170000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000338059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":55,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2012,11,1]]},"published-print":{"date-parts":[[2012,11,16]]}},"URL":"https:\/\/doi.org\/10.1159\/000338059","archive":["Portico"],"relation":{},"ISSN":["1422-6405","1422-6421"],"issn-type":[{"type":"print","value":"1422-6405"},{"type":"electronic","value":"1422-6421"}],"subject":[],"published":{"date-parts":[[2012]]}}}