{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T12:51:59Z","timestamp":1779367919258,"version":"3.53.0"},"reference-count":29,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>To discuss a cure for IBD, one should first define the concept \u2018a cure\u2019. If it is intended as the general restoration of health, this is already possible, as many current therapies do a good job in inducing long periods of remission in Crohn\u2019s disease, and colectomy can technically cure ulcerative colitis. If it is more strictly defined as the complete and permanent elimination of the cause, predisposing and permissive factors, reinstatement of normal microbial ecology and restoration of mucosal immune homeostasis, then a cure for IBD is out of reach, at least for now. Regardless of the definition, major strides have been made in attempting to cure IBD by addressing the key components of its pathogenesis: the environment (exposome), the genetic makeup (genome), the gut microbiota (microbiome) and the immune system (immunome). However, the isolated modulation of each component is insufficient to provide a cure, and different requirements may be needed depending on the stage of the disease and each patient subset. To achieve a cure, one key approach is currently missing: the integration of knowledge from all the pathogenic components. We continue to learn more and more about each component using traditional \u2018canonical\u2019 systems, which allow the accumulation of data without taking into consideration the other components. We are still not studying the \u2018omes\u2019 of IBD, we should be using \u2018omics\u2019 technologies that can generate a more global vision of IBD pathogenesis on which to base novel, multiple pathway-integrated therapies.<\/jats:p>","DOI":"10.1159\/000338148","type":"journal-article","created":{"date-parts":[[2012,7,13]],"date-time":"2012-07-13T15:29:29Z","timestamp":1342193369000},"page":"428-433","source":"Crossref","is-referenced-by-count":22,"title":["Towards a \u2018Cure\u2019 for IBD"],"prefix":"10.1159","volume":"30","author":[{"given":"Claudio","family":"Fiocchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2012,7,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038%2Fnature06005"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.gastro.2011.02.046"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002%2Fibd.21375"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.gastro.2004.01.063"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038%2F35021206"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.296.5567.490"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1186%2F1741-7007-7-79"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.2010.219683"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI58719"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.0504978102"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038%2Fnature05414"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002%2Fibd.21539"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.1208344"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038%2F453046a"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.gastro.2011.04.007"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097%2F00001574-200107000-00006"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.1201291"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa1103849"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038%2Fni.1703"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cell.2010.02.029"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1038%2Fjes.2010.50"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038%2Fnrg3000"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.it.2011.04.001"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.1206843"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.gastro.2008.08.030"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1097%2FMOG.0b013e3283483986"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007%2F978-1-61779-027-0_1"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1038%2Fni0511-369"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMe078114"}],"container-title":["Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/338148","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/338148","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:16:35Z","timestamp":1745432195000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000338148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":29,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2012,7,1]]},"published-print":{"date-parts":[[2012,7,13]]}},"URL":"https:\/\/doi.org\/10.1159\/000338148","archive":["Portico"],"relation":{},"ISSN":["0257-2753","1421-9875"],"issn-type":[{"value":"0257-2753","type":"print"},{"value":"1421-9875","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}