{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T01:47:54Z","timestamp":1781920074384,"version":"3.54.5"},"reference-count":21,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Therapeutic evidence for toxic epidermal necrolysis (TEN) is indicative for high-dose intravenous immunoglobulin yet inconclusive for corticosteroids. &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; To describe the combination of corticosteroids, infliximab and a high-dose intravenous immunoglobulin course for TEN. &lt;b&gt;&lt;i&gt;Patients and Methods:&lt;\/i&gt;&lt;\/b&gt; In three patients (SCORTEN survival probabilities: 41.7%, 64.2%, 41.7%) disease control was evaluated by (a) employing quantitative image analysis to measure progression of skin detachment and (b) patients\u2019 outcome (complete re-epithelization). Published cases of TEN treatments with infliximab were retrieved from PubMed. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Within 48 h skin disease progression was arrested in all patients. Two patients were discharged after 3 weeks without any sequels from skin or conjunctivae. One patient passed away on the ninth day, however with noticeably improved skin (mortality rate: 33% observed vs. 50% expected). A PubMed search retrieved five TEN patients treated successfully with infliximab. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; The described combination presents a feasible therapeutic alternative for TEN that warrants further evaluation.<\/jats:p>","DOI":"10.1159\/000338202","type":"journal-article","created":{"date-parts":[[2012,5,3]],"date-time":"2012-05-03T08:13:38Z","timestamp":1336032818000},"page":"134-139","source":"Crossref","is-referenced-by-count":27,"title":["Treatment of Toxic Epidermal Necrolysis with the Combination of Infliximab and High-Dose Intravenous Immunoglobulin"],"prefix":"10.1159","volume":"224","author":[{"given":"Georgios","family":"Gaitanis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiota","family":"Spyridonos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Patmanidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasilios","family":"Koulouras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Nakos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Tzaphlidou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis D.","family":"Bassukas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2012,5,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2006.04.048"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2005.06721.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1747.2000.00061.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.282.5388.490"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1529-8019.2011.01396.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2133.2002.46833.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2005.06.029"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1346-8138.2010.00893.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1346-8138.2009.00616.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1088%2F0266-5611%2F24%2F3%2F034008"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1067%2Fmai.2001.118796"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2898%2902197-7"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2006.07398.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.130.5.605"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI38482"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038%2Fnm.1884"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159%2F000284592"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1440-1711.2001.01020.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1159%2F000200022"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1080%2F03009740601089234"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1001%2Farchdermatol.2011.1610"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/338202","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/338202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:17:08Z","timestamp":1745432228000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000338202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":21,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,5,1]]},"published-print":{"date-parts":[[2012,5,31]]}},"URL":"https:\/\/doi.org\/10.1159\/000338202","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.5123497","asserted-by":"subject"}]},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}