{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:33:48Z","timestamp":1745469228085,"version":"3.40.4"},"reference-count":12,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cytologica"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; Squamous intraepithelial lesions (SILs) are classified as low-grade SIL (LGSIL) and high-grade SIL (HGSIL). \u2018LGSIL cannot exclude high grade\u2019 (LGSIL-H) interpretive category has been used in cases where findings exceed criteria for LGSIL, but do not fulfill the criteria for HGSIL. This study analyzed follow-up histology of LGSIL-H cases and compared the follow-up results of LGSIL-H with LGSIL to determine the utility of LGSIL-H category using a single institution\u2019s experience. &lt;b&gt;&lt;i&gt;Study Design:&lt;\/i&gt;&lt;\/b&gt; Pap smears with LGSIL-H interpretation from 2005 to 2008 were retrieved. Histological follow-up results for LGSIL-H cases were analyzed and compared to the follow-up results of LGSIL cases. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Cases with LGSIL-H interpretation (311) comprised 0.18% of all cases (170,307). Follow-up was available for 144 patients and 13.2% had benign findings, 51.4% had cervical intraepithelial neoplasia (CIN) 1, and 35.4% had CIN 2 or higher. In comparison, of 425 patients with LGSIL, 22.6% had benign findings, 71% had CIN 1 and 6.4% had CIN 2 or higher. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; A significantly greater number of patients with LGSIL-H interpretation had a CIN 2 or higher lesion on follow-up compared to patients with LGSIL. This suggests LGSIL-H may be a useful diagnostic category.<\/jats:p>","DOI":"10.1159\/000338212","type":"journal-article","created":{"date-parts":[[2012,7,25]],"date-time":"2012-07-25T08:18:20Z","timestamp":1343204300000},"page":"383-387","source":"Crossref","is-referenced-by-count":4,"title":["The Utility of \u2018Low-Grade Intraepithelial Lesion, Cannot Exclude High Grade\u2019 Diagnosis: A Single Institution\u2019s Experience"],"prefix":"10.1159","volume":"56","author":[{"given":"Alexander","family":"Finkelstein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa B.","family":"Bajor-Dattilo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael C.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Szeto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Elgert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kasturi","family":"Das","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,7,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.287.16.2114"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097%2FLGT.0b013e3181585870"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0339%28200010%2923%3A4%3C245%3A%3AAID-DC6%3E3.0.CO%3B2-7"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncr.11721"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ajog.2008.03.060"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncr.22169"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncy.20004"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1309%2FQRDNMWWAKJQTVJGF"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.4132%2FKoreanJPathol.2010.44.5.528"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186%2F1742-6413-4-7"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ygyno.2010.12.004"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093%2Fjnci%2F92.5.397"}],"container-title":["Acta Cytologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/338212","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/338212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:17:17Z","timestamp":1745432237000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000338212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":12,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2012,8,1]]},"published-print":{"date-parts":[[2012,8,29]]}},"URL":"https:\/\/doi.org\/10.1159\/000338212","archive":["Portico"],"relation":{},"ISSN":["0001-5547","1938-2650"],"issn-type":[{"type":"print","value":"0001-5547"},{"type":"electronic","value":"1938-2650"}],"subject":[],"published":{"date-parts":[[2012]]}}}