{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:33:48Z","timestamp":1745469228755,"version":"3.40.4"},"reference-count":25,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>More than 70 different mixed lineage leukemia &lt;i&gt;(MLL)&lt;\/i&gt; rearrangements involving 11q23 have been molecularly characterized in acute leukemia. Among these, the &lt;i&gt;MLLT11&lt;\/i&gt; gene is highly unique as &lt;i&gt;MLL&lt;\/i&gt; fusion partner because the entire open reading frame is usually fused in-frame to the N-terminal portion of the &lt;i&gt;MLL&lt;\/i&gt; gene. By using molecular genetic methods, we identified the chromosomal fusion site within &lt;i&gt;MLL&lt;\/i&gt; exon 10 sequences which were fused to the &lt;i&gt;MLLT11&lt;\/i&gt; intron 1 sequences. This unusual break site results in the creation of two in-frame &lt;i&gt;MLL&lt;\/i&gt;-&lt;i&gt;MLLT11&lt;\/i&gt; fusion transcripts in this acute myeloid leukemia patient with t(1;11)(q21;q23). One fusion transcript represents a normal splice product, while the other contains intronic sequences and a cryptic splice event in order to generate an intact fusion transcript. We also reviewed all published articles which have reported t(1;11)(q21;q23) in myeloid or lymphoid neoplasm and attempted to summarize these published data. Of interest, pediatric patients displayed a significant larger portion of unique balanced translocations (n = 40), while complex karyotypes were less often identified (n = 12). Vice versa, in adult leukemia patients, complex karyotypes (n = 5) were more frequent than unique balanced translocations (n = 2).<\/jats:p>","DOI":"10.1159\/000338258","type":"journal-article","created":{"date-parts":[[2012,8,2]],"date-time":"2012-08-02T08:38:16Z","timestamp":1343896696000},"page":"131-138","source":"Crossref","is-referenced-by-count":1,"title":["Molecular Identification of a New Splicing Variant of the &lt;b&gt;&lt;i&gt;MLL&lt;\/i&gt;&lt;\/b&gt;-&lt;b&gt;&lt;i&gt;MLLT11&lt;\/i&gt;&lt;\/b&gt; Fusion Transcript in an Adult with Acute Myeloid Leukemia and t(1;11)(q21;q23)"],"prefix":"10.1159","volume":"128","author":[{"given":"Sang-Guk","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae Sung","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John 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