{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T14:17:55Z","timestamp":1781014675235,"version":"3.54.1"},"reference-count":32,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2012]]},"abstract":"<b><i>Background:<\/i><\/b> The incidence and severity of herpes zoster (HZ) appear increased in patients receiving tumor necrosis factor-\u03b1 antagonists. <b><i>Objective:<\/i><\/b> To study the incidence and clinical features of HZ in 1,220 patients (4,206 patient-years) receiving either adalimumab, etanercept, infliximab, rituximab or ustekinumab. <b><i>Results:<\/i><\/b> Twenty-two HZ cases were identified [1.26% of total cohort; adalimumab: 11\/1,546 patient-years, incidence rate (IR) 7.1; etanercept: 4\/789 patient-years, IR 5.1; rituximab: 1\/168 patient-years, IR 5.2; ustekinumab: 2\/37 patient-years, IR 53.5; infliximab: 4\/1,666 patient-years, IR 2.4]. The time to event varied widely (1.5\u2013 108 months). Extensive HZ was reported in 45 and 32% of the cases, respectively. Persistent postzoster neuralgia (PHN; >6 months) was observed in 5\/20 patients. <b><i>Conclusions:<\/i><\/b> The HZ incidence was 2.1-fold higher among patients over 60 years, compared with a reference population, although not statistically significant. 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