{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T06:01:09Z","timestamp":1757311269141,"version":"3.40.4"},"reference-count":15,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Recently, reports have indicated that the continuous use of topical calcineurin inhibitors such as tacrolimus may induce rosacea-like dermatitis (RD). &lt;b&gt;&lt;i&gt;Objective and Methods:&lt;\/i&gt;&lt;\/b&gt; To assess clinical features of RD associated with tacrolimus, 44 cases of patients diagnosed with RD between 2005 and 2010 at our hospital were retrospectively reviewed. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; In total, 22 cases were caused by topical steroid use, 8 by topical tacrolimus use, and 8 by consecutive treatment with topical steroids and tacrolimus. Clinical presentation was basically similar among the 3 groups, although the nose was less frequently affected and pustules were rarely observed in the latter 2 sets of cases. &lt;i&gt;Demodex&lt;\/i&gt; mites were often found in smears of skin lesions from patients with RD caused by steroids and tacrolimus. Treatment with topical metronidazole was effective in most RD patients. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Topical tacrolimus is becoming an important cause of RD along with topical steroids.<\/jats:p>","DOI":"10.1159\/000338693","type":"journal-article","created":{"date-parts":[[2012,5,21]],"date-time":"2012-05-21T13:11:18Z","timestamp":1337605878000},"page":"309-314","source":"Crossref","is-referenced-by-count":30,"title":["Tacrolimus-Induced Rosacea-Like Dermatitis: A Clinical Analysis of 16 Cases Associated with Tacrolimus Ointment Application"],"prefix":"10.1159","volume":"224","author":[{"given":"Yuichi","family":"Teraki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhiro","family":"Hitomi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiichi","family":"Izaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,5,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-4362.2003.01852.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.clindermatol.2010.09.007"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159%2F000071799"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.139.2.229"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.140.4.457"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2005.04.053"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2009.01.029"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.1993.tb00261.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2F0190-9622%2893%2970065-2"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2005.04.059"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1517%2F14656566.5.10.2127"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159%2F000323009"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1067%2Fmjd.2001.114739"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2008.03.043"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.2165%2F00128071-200001030-00007"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/338693","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/338693","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:21:52Z","timestamp":1745432512000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000338693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":15,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2012,8,1]]},"published-print":{"date-parts":[[2012,8,2]]}},"URL":"https:\/\/doi.org\/10.1159\/000338693","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"type":"print","value":"1018-8665"},{"type":"electronic","value":"1421-9832"}],"subject":[],"published":{"date-parts":[[2012]]}}}