{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T08:06:06Z","timestamp":1784189166993,"version":"3.55.0"},"reference-count":37,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Although plasma \u03b2-amyloid (A\u03b2) has been suggested to be a noninvasive diagnostic biomarker for Alzheimer\u2019s disease (AD), its significance and validity have been inconclusive. Thus, it is quite important to establish a novel diagnostic method related to plasma A\u03b2. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; As our previous animal studies demonstrated a relation of glucose with plasma A\u03b2, we examined the effect of glucose loading on plasma A\u03b2 levels in AD patients. After fasting, an oral glucose load was administered to AD patients and non-AD dementia patients, and subsequently, blood glucose, plasma insulin, and plasma A\u03b2 levels were measured. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The plasma levels of baseline blood glucose, plasma insulin, and plasma A\u03b2 were not different between the two groups. However, immediately after glucose loading, a significant increase in plasma A\u03b240 and A\u03b242 levels was observed in AD patients, whereas a mild decrease in plasma A\u03b240 and A\u03b242 levels was detected in non-AD dementia patients. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; The present study clearly demonstrated a different response in plasma A\u03b240 and A\u03b242 levels after glucose loading between AD and non-AD dementia patients, which is consistent with our previous animal studies. These findings suggest a novel diagnostic tool for AD using the elevation of plasma A\u03b2 level after glucose loading, although further studies are necessary.<\/jats:p>","DOI":"10.1159\/000338704","type":"journal-article","created":{"date-parts":[[2012,8,9]],"date-time":"2012-08-09T08:16:53Z","timestamp":1344500213000},"page":"25-30","source":"Crossref","is-referenced-by-count":27,"title":["Oral Glucose Loading Modulates Plasma \u03b2-Amyloid Level in Alzheimer\u2019s Disease Patients: Potential Diagnostic Method for Alzheimer\u2019s 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