{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:41:59Z","timestamp":1790196119037,"version":"4.1.0"},"reference-count":22,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Neurosurg"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>Hypothalamic hamartomas have been reported to coexist with lesions like Rathke\u2019s cleft cyst and arachnoid cysts in the suprasellar or temporo-sylvian regions. This is the first report in indexed literature describing its association with a suprasellar teratoma. A 7-year-old girl presented with long-standing precocious puberty and generalized tonic-clonic seizures and recent-onset raised intracranial pressure. MRI done prior to the onset of symptomatic raised intracranial pressure revealed 2 distinct lesions in the suprasellar region. One was a midline, pedunculated lesion arising from the hypothalamus, with evidence of an old bleed within it. A separate lesion, with a wide base near the tuberculum sellae and a posteriorly directed conical tip, was noted in an adjacent sagittal cut. CT scan done at the time of admission demonstrated a re-bleed in the suprasellar region with blood in the lateral and third ventricles and gross hydrocephalus. The child was taken up for a ventriculoperitoneal shunt followed by complete excision of the lesions. Histopathologic examination confirmed the pedunculated lesion to be a hypothalamic hamartoma with evidence of hemorrhage, and the other to be a mature teratoma. Postoperative MRI confirmed complete excision of both the lesions. The child reported regression of precocious puberty and remained seizure-free until the last follow-up 6 months after surgery. A hypothesis based on a dysontogenetic mechanism is discussed to explain the unusual occurrence of the dual, seemingly unrelated pathologies. Hemorrhage into the hamartoma was an added oddity in this case.<\/jats:p>","DOI":"10.1159\/000338896","type":"journal-article","created":{"date-parts":[[2012,7,9]],"date-time":"2012-07-09T09:34:11Z","timestamp":1341826451000},"page":"430-435","source":"Crossref","is-referenced-by-count":3,"title":["Synchronous Occurrence of a Hemorrhagic Hypothalamic Hamartoma and a Suprasellar Teratoma"],"prefix":"10.1159","volume":"47","author":[{"given":"Narayanam Anantha","family":"Sai Kiran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nandita","family":"Ghosal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumit","family":"Thakar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alangar S.","family":"Hegde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2012,7,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1515%2Fjpem.2010.073"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2Fajmg.1320070111"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3171%2F2011.1.FOCUS10240"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159%2F000085166"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007%2Fs003810050446"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.2176%2Fnmc.36.725"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1054%2Fjocn.2000.0771"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.4103%2F0028-3886.73740"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.2176%2Fnmc.41.356"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3171%2Fjns.1998.89.5.0844"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3171%2Fspi.2007.6.6.12"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007%2Fs002340000350"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097%2F00000478-199812000-00011"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3171%2Fped.2004.100.5.0525"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1080%2F02688699845564"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3171%2FPED%2F2008%2F1%2F3%2F244"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.2176%2Fnmc.37.849"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.58.6.761"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1212%2FWNL.27.7.650"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2F0039-6257%2881%2990123-5"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3171%2F2010.11.FOCUS10244"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1227%2F01.neu.0000318170.82719.7c"}],"container-title":["Pediatric Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/338896","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/338896","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:23:23Z","timestamp":1745432603000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000338896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":22,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2012,7,1]]},"published-print":{"date-parts":[[2012,7,25]]}},"URL":"https:\/\/doi.org\/10.1159\/000338896","archive":["Portico"],"relation":{},"ISSN":["1016-2291","1423-0305"],"issn-type":[{"value":"1016-2291","type":"print"},{"value":"1423-0305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}