{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:27:27Z","timestamp":1759940847008,"version":"3.40.4"},"reference-count":10,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2013]]},"abstract":"<b><i>Background:<\/i><\/b> Long-term follow-up of diisocyanate-induced occupational asthma has been occasionally reported. <b><i>Methods:<\/i><\/b> We studied the outcome of toluene diisocyanate (TDI)-induced asthma in 46 patients at diagnosis and after a follow-up of 11 \u00b1 3.6 years. Symptoms, anti-asthma therapy, forced expiratory volume in 1 s (FEV<sub>1<\/sub>) and bronchial hyperresponsiveness to methacholine were assessed. <b><i>Results:<\/i><\/b> A significant improvement in FEV<sub>1<\/sub> (% predicted) and PD20FEV<sub>1<\/sub> methacholine was observed at follow-up in comparison with diagnosis. Anti-asthma treatment was performed by 42% of patients at diagnosis and by 70% at follow-up. At the time of follow-up, 32 subjects had been removed from exposure for 6.0 \u00b1 6.9 years, whereas 14 subjects continued to work with reduced exposure to TDI. There was a significant reduction in the prevalence of attacks of shortness of breath and dyspnoea at follow-up, but only in unexposed patients. PD20FEV<sub>1<\/sub> was significantly improved only in patients with a lower FEV<sub>1<\/sub> at diagnosis and in those who have ceased work. Logistic regression analysis, using different models with some independent variables, showed that there were no significant determinants of improvement in FEV<sub>1<\/sub> at follow-up, while a shorter duration of symptoms before diagnosis was a significant predictor of improvement in PD20FEV<sub>1<\/sub> at follow-up. <b><i>Conclusions:<\/i><\/b> Asthma-like symptoms, bronchial hyperresponsiveness and airway obstruction improved, but did not normalize, after a long-term follow-up with cessation or reduction in TDI exposure, mainly in subjects with an early diagnosis of occupational asthma and in patients with a lower baseline FEV<sub>1<\/sub> no longer exposed to TDI.<\/jats:p>","DOI":"10.1159\/000338993","type":"journal-article","created":{"date-parts":[[2013,1,23]],"date-time":"2013-01-23T10:37:20Z","timestamp":1358937440000},"page":"189-194","source":"Crossref","is-referenced-by-count":6,"title":["Mild Improvement in Symptoms and Pulmonary Function in a Long-Term Follow-Up of Patients with Toluene Diisocyanate-Induced Asthma"],"prefix":"10.1159","volume":"161","author":[{"given":"D.","family":"Talini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Novelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Bacci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.L.","family":"Dente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Di Franco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Malagrin\u00f2","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Vagaggini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Paggiaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2013,1,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.08-0201"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1183%2F09031936.03.00060703"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1164%2Frccm.200312-1749OC"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136%2Fthx.2006.061952"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2F0091-6749%2887%2990212-0"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136%2Foem.54.10.756"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1183%2F09031936.05.00034805"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2008.01.012"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.2007.01606.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136%2Foem.2004.016287"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/338993","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/338993","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:24:22Z","timestamp":1745432662000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000338993"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":10,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,5,1]]},"published-print":{"date-parts":[[2013,5,15]]}},"URL":"https:\/\/doi.org\/10.1159\/000338993","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"type":"print","value":"1018-2438"},{"type":"electronic","value":"1423-0097"}],"subject":[],"published":{"date-parts":[[2013]]}}}