{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T21:17:18Z","timestamp":1760044638459,"version":"3.40.4"},"reference-count":9,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cytologica"],"published-print":{"date-parts":[[2012]]},"abstract":"<b><i>Objective:<\/i><\/b> To evaluate the cytological characteristics of each type of thymoma and introduce an algorithm to classify thymoma using fine needle aspiration biopsy (FNAB). <b><i>Study Design:<\/i><\/b> We retrospectively reviewed the cytological characteristics of 15 cases of thymoma with three thymic carcinoma (1 type A thymoma, 6 type AB thymomas and 8 type B thymomas), which were confirmed by histology. Three major and one minor cytomorphologic parameter were adopted for classification: (1) number of lymphocytes in the smear background; (2) nuclear characteristics of thymic cells; (3) lymphocytes and crush artifacts in thymic cell clusters, and (4) nuclear arrangement of thymic cells. <b><i>Results:<\/i><\/b> An abundant lymphocytic smear background indicated type B thymomas in 87.5% of cases, contrary to the few lymphocytes in the remaining thymic tumors excluding type B thymomas (90%). Thymic cells contained no vesicular nuclei and inconspicuous nucleoli in 85.7% of type A thymoma and type AB thymoma cases. Type AB thymomas and type B thymomas showed more prominent crush artifacts in cell clusters than type A thymoma and thymic carcinoma. Thymic cells of type B thymomas and thymic carcinoma were arranged without whirling architecture in clusters. The proposed algorithm demonstrated a predictive rate of 88.8% for thymoma classification. <b><i>Conclusions:<\/i><\/b> The stepwise classification of thymoma with FNAB may be useful in patients for whom an invasive diagnosis approach is not feasible.<\/jats:p>","DOI":"10.1159\/000339001","type":"journal-article","created":{"date-parts":[[2012,9,27]],"date-time":"2012-09-27T00:35:42Z","timestamp":1348706142000},"page":"487-494","source":"Crossref","is-referenced-by-count":12,"title":["Classification of Thymoma by Fine Needle Aspiration Biopsy According to WHO Classification: A Cytological Algorithm for Stepwise Analysis in the Classification of Thymoma"],"prefix":"10.1159","volume":"56","author":[{"given":"Han Suk","family":"Ryu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Soo","family":"Koh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunhoo","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Suk","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo Youn","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung-Sook","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,9,27]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1016%2Fj.athoracsur.2003.07.042"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1016%2FS0022-5223%2803%2900798-0"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1159%2F000331958"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1002%2F%28SICI%291097-0142%2820000225%2990%3A1%3C24%3A%3AAID-CNCR4%3E3.0.CO%3B2-A"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1016%2FS0344-0338%2899%2980001-6"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1016%2Fj.hoc.2008.03.003"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.1046%2Fj.1365-2559.2000.00846.x"},{"doi-asserted-by":"publisher","key":"ref8","DOI":"10.1186%2F1746-1596-2-13"},{"doi-asserted-by":"publisher","key":"ref9","DOI":"10.1002%2Fcncr.10665"}],"container-title":["Acta Cytologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/339001","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/339001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:24:26Z","timestamp":1745432666000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000339001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":9,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2012,10,1]]},"published-print":{"date-parts":[[2012,10,12]]}},"URL":"https:\/\/doi.org\/10.1159\/000339001","archive":["Portico"],"relation":{},"ISSN":["0001-5547","1938-2650"],"issn-type":[{"type":"print","value":"0001-5547"},{"type":"electronic","value":"1938-2650"}],"subject":[],"published":{"date-parts":[[2012]]}}}