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The aim of this work was to evaluate the efficacy of allopurinol to reverse the experimental cirrhosis induced by CCl&lt;sub&gt;4&lt;\/sub&gt;. Rats received CCl&lt;sub&gt;4&lt;\/sub&gt; for 8 weeks, and immediately after allopurinol was administered for 4 weeks more. Allopurinol reversed all markers of liver damage and oxidative stress to normal values, restoring the metabolic capacity of the liver. Chronic injury by CCl&lt;sub&gt;4&lt;\/sub&gt; induced significant overexpression of profibrogenic cytokine TGF-\u00df, while allopurinol decreased this production and consequently decreased the collagen content. Moreover, allopurinol is capable of partially inhibiting NF-&amp;#954;B. These findings suggest that allopurinol is capable of reversing the cirrhosis induced by CCl&lt;sub&gt;4&lt;\/sub&gt;, modulating oxidative stress, TGF-\u00df expression and NF-&amp;#954;B nuclear translocation.<\/jats:p>","DOI":"10.1159\/000339078","type":"journal-article","created":{"date-parts":[[2013,9,5]],"date-time":"2013-09-05T08:05:20Z","timestamp":1378368320000},"page":"138-149","source":"Crossref","is-referenced-by-count":20,"title":["Allopurinol Reverses Liver Damage Induced by Chronic Carbon Tetrachloride Treatment by Decreasing Oxidative Stress, TGF-\u00df Production and NF-&amp;#954;B Nuclear Translocation"],"prefix":"10.1159","volume":"92","author":[{"given":"Liseth R.","family":"Aldaba-Muruato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario 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