{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:16:27Z","timestamp":1759940187178,"version":"3.40.4"},"reference-count":22,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Little is known about the effects of hypothermia on the cardiovascular system in term newborns with neonatal encephalopathy. &lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; To evaluate whether mild hypothermia for neonatal encephalopathy is cardioprotective as indicated by the cardiac biomarkers cardiac troponin I (cTnI) and B-type natriuretic peptide (BNP). &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; This was an observational cohort study of infants treated for perinatal asphyxia. In infants, mild total body hypothermia treatment of 33.5\u00b0C during 72 h was initiated (n = 20). Samples of cTnI and BNP were collected before the start of hypothermia, at 24 and 48 h after birth, and after rewarming (84 h). BNP and cTnI values were then compared with BNP and cTnI values of asphyxiated infants not treated with hypothermia (n = 28). &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; No differences were found between the groups in clinical patient characteristics or inotropic support. The hypothermia-treated patients seemed to be clinically more affected (5-min Apgar score, p &lt; 0.05; umbilical artery pH, p = 0.08), but showed similar encephalopathy scores. Significantly lower values for BNP were found in hypothermia- compared to nonhypothermia-treated infants at 48 h and at normothermia after rewarming [144 pmol\/l (95\u2013286) vs. 75 pmol\/l (45\u2013143), 182 pmol\/l (73\u2013341) vs. 43 pmol\/l (24\u2013163)]. No differences were found for cTnI concentrations between both groups. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; The raised, but similar, cTnI values between hypothermia- and nonhypothermia-treated infants indicate similar myocardial damage in both groups. The lower BNP levels during hypothermia treatment suggest that hypothermia after perinatal asphyxia exerts a beneficial effect on cardiac function.<\/jats:p>","DOI":"10.1159\/000339117","type":"journal-article","created":{"date-parts":[[2012,8,15]],"date-time":"2012-08-15T07:13:27Z","timestamp":1345014807000},"page":"243-248","source":"Crossref","is-referenced-by-count":21,"title":["Cardiac Biomarkers as Indicators of Hemodynamic Adaptation during Postasphyxial Hypothermia Treatment"],"prefix":"10.1159","volume":"102","author":[{"given":"D.C.","family":"Vijlbrief","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.J.N.L.","family":"Benders","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Kemperman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"van Bel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.B.","family":"de Vries","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,8,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002%2F14651858.CD003311.pub2"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2004-0525"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jpeds.2011.06.038"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1203%2FPDR.0b013e3181799594"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.pharmthera.2004.04.004"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159%2F000089795"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1651-2227.2011.02432.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2004-1587"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.106.1.92"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159%2F000329818"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.pediatrneurol.2004.06.015"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038%2Fpr.2011.577"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159%2F000063609"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1651-2227.1997.tb08581.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136%2Fheart.89.8.875"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159%2F000079068"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jacc.2009.06.020"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.2006.106039"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038%2Fjp.2008.21"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1159%2F000089549"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1651-2227.2007.00361.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-199701000-00015"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/339117","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/339117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:26:00Z","timestamp":1745432760000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000339117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":22,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2012,11,1]]},"published-print":{"date-parts":[[2012,11,13]]}},"URL":"https:\/\/doi.org\/10.1159\/000339117","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"type":"print","value":"1661-7800"},{"type":"electronic","value":"1661-7819"}],"subject":[],"published":{"date-parts":[[2012]]}}}