{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T12:09:36Z","timestamp":1761394176844,"version":"3.40.4"},"reference-count":109,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroendocrinology"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Anabolic androgenic steroids (AAS) comprise a large and growing class of synthetic androgens used clinically to promote tissue-building in individuals suffering from genetic disorders, injuries, and diseases. Despite these beneficial therapeutic applications, the predominant use of AAS is illicit: these steroids are self-administered to promote athletic performance and body image. Hand in hand with the desired anabolic actions of the AAS are untoward effects on the brain and behavior. While the signaling routes by which the AAS impose both beneficial and harmful actions may be quite diverse, key endpoints are likely to include ligand-gated and voltage-dependent ion channels that govern the activity of electrically excitable tissues. Here, we review the known effects of AAS on molecular targets that play critical roles in controlling electrical activity, with a specific focus on the effects of AAS on neurotransmission mediated by GABA&lt;sub&gt;A&lt;\/sub&gt; receptors in the central nervous system.<\/jats:p>","DOI":"10.1159\/000339123","type":"journal-article","created":{"date-parts":[[2012,5,4]],"date-time":"2012-05-04T08:56:11Z","timestamp":1336121771000},"page":"141-151","source":"Crossref","is-referenced-by-count":6,"title":["The Buzz about Anabolic Androgenic Steroids: Electrophysiological Effects in Excitable Tissues"],"prefix":"10.1159","volume":"96","author":[{"given":"Joseph G.","family":"Oberlander","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos A.A.","family":"Penatti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna M.","family":"Porter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie P.","family":"Henderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,5,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.86.11.5108"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0149-2918%2801%2980114-4"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1517%2F13543784.2011.544651"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.2165%2F00023210-200519070-00002"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.drugalcdep.2008.05.004"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1001%2Farchpsyc.58.2.172"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2003-032175"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2F0960-0760%2893%2990075-8"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1677%2Fjoe.0.0370037"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0960-0760%2802%2900221-2"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0039-128X%2802%2900184-8"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1210%2Fendo-114-6-2100"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0006-8993%2898%2900148-6"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.steroids.2008.10.016"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jsbmb.2009.11.008"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1095%2Fbiolreprod64.5.1460"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.0409643102"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1523%2FJNEUROSCI.3108-09.2009"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.pbb.2010.02.020"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1210%2Fen.2005-1524"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1210%2Fen.141.9.3377"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2FS0960-0760%2801%2900162-5"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1002%2Fmrd.20642"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1210%2Fen.2010-1501"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neuropharm.2007.01.022"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016%2F0024-3205%2895%2902326-7"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1006%2Fhbeh.1993.1041"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.3389%2Ffnins.2011.00131"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016%2F0304-3940%2895%2911445-3"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016%2FS0028-3908%2802%2900155-7"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neuropharm.2005.03.017"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1113%2Fjphysiol.2006.106534"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neuroscience.2005.07.021"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016%2FS0166-2236%2896%2980037-3"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.psyneuen.2009.08.010"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1471-4159.2007.04833.x"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1016%2FS0165-6147%2800%2989058-6"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1016%2FS0149-7634%2803%2900064-2"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.brainres.2006.08.081"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.mce.2009.12.003"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.conb.2010.04.004"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2826.2011.02145.x"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1016%2FS1054-139X%2801%2900414-1"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.yhbeh.2008.01.010"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1210%2Fen.2008-1708"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1523%2FJNEUROSCI.5383-09.2010"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neuropharm.2011.05.008"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1146%2Fannurev.neuro.25.112701.142745"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1002%2Fcne.902940107"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1460-9568.2008.06216.x"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1210%2Fen.2007-0403"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.brainresrev.2007.05.006"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neuroscience.2009.03.039"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1016%2FS0361-9230%2897%2900210-4"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1159%2F000012362"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.eurpsy.2005.09.001"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1097%2F00042752-199501000-00005"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1038%2Fnpp.2011.334"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1038%2Fnpp.2009.109"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.psyneuen.2010.04.015"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.biopsych.2009.11.007"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.0437926100"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1523%2FJNEUROSCI.3004-04.2004"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.biopsych.2011.10.032"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.alcohol.2010.11.002"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.0801853105"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.0600329103"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1097%2FWNR.0b013e32832a2393"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.biopsych.2009.04.003"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1016%2FS0028-3908%2802%2900154-5"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1097%2F01.wnr.0000234752.03808.b2"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.yhbeh.2011.10.004"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.142288699"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.0508752102"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1460-9568.2007.05970.x"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neuroscience.2011.03.051"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neuropharm.2010.01.015"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bbrc.2007.04.037"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neuroscience.2010.12.041"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neuron.2010.08.012"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ygcen.2011.02.022"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.1016%2FS0079-6123%2808%2981006-0"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.brainres.2010.08.036"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1159%2F000337663"},{"key":"ref85","doi-asserted-by":"publisher","DOI":"10.1016%2F0006-8993%2888%2991501-6"},{"key":"ref86","doi-asserted-by":"publisher","DOI":"10.1210%2Fen.134.6.2547"},{"key":"ref87","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2826.2011.02270.x"},{"key":"ref88","doi-asserted-by":"publisher","DOI":"10.1159%2F000093155"},{"key":"ref89","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.84.24.9295"},{"key":"ref90","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.yhbeh.2005.05.022"},{"key":"ref91","doi-asserted-by":"publisher","DOI":"10.1002%2Fdneu.20530"},{"key":"ref92","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.yjmcc.2010.04.014"},{"key":"ref93","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00421-005-0111-7"},{"key":"ref94","doi-asserted-by":"publisher","DOI":"10.2170%2Fjjphysiol.53.77"},{"key":"ref95","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00424-003-1114-z"},{"key":"ref96","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.0953-816x.2001.01877.x"},{"key":"ref97","doi-asserted-by":"publisher","DOI":"10.1097%2F00005768-200301000-00006"},{"key":"ref98","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.brainres.2008.10.053"},{"key":"ref99","doi-asserted-by":"publisher","DOI":"10.1016%2FS0304-3940%2897%2900244-9"},{"key":"ref100","doi-asserted-by":"publisher","DOI":"10.1016%2FS0306-4522%2803%2900120-9"},{"key":"ref101","doi-asserted-by":"publisher","DOI":"10.1037%2F0735-7044.119.5.1184"},{"key":"ref102","doi-asserted-by":"publisher","DOI":"10.1037%2F0735-7044.120.6.1242"},{"key":"ref103","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1601-183X.2008.00458.x"},{"key":"ref104","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bbr.2008.11.048"},{"key":"ref105","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.0953-816X.2000.01402.x"},{"key":"ref106","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.yhbeh.2008.10.011"},{"key":"ref107","doi-asserted-by":"publisher","DOI":"10.1097%2FFBP.0b013e32833b10f1"},{"key":"ref108","doi-asserted-by":"publisher","DOI":"10.1037%2Fa0020899"},{"key":"ref109","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.mce.2009.07.027"}],"container-title":["Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/339123","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/339123","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/339123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:26:03Z","timestamp":1745432763000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000339123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":109,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,9,1]]},"published-print":{"date-parts":[[2012,9,14]]}},"URL":"https:\/\/doi.org\/10.1159\/000339123","archive":["Portico"],"relation":{},"ISSN":["0028-3835","1423-0194"],"issn-type":[{"type":"print","value":"0028-3835"},{"type":"electronic","value":"1423-0194"}],"subject":[],"published":{"date-parts":[[2012]]}}}