{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T16:12:47Z","timestamp":1773850367786,"version":"3.50.1"},"reference-count":23,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Objective: To determine predisposing or prognostic factors and mortality rates of patients with Fournier\u2019s gangrene compared to other necrotizing soft tissue infections (NSTI). Material and Methods: Data of 55 intensive care patients (1981\u20132010) with NSTI were evaluated. Data were collected prospectively. Results: 43.4% of the patients were in septic condition and 27.3% were hemodynamically unstable. Half of the patients showed predisposing factors (52.7%). The lower extremity (63.2%), abdomen (30.9%), and perineum (14.5%) were most affected. Polymicrobial infections were frequent (65.5%, mean 2.8, range: 1\u20134). The mortality rate was 16.4% (n = 9). An increase was shown for diabetes mellitus (20%), cardiac insufficiency (22.3%), septic condition at presentation (33.3%), abdominal affection (47.1%), and hemodynamic instability (46.7%). Comparing survivors and nonsurvivors, statistical significance was seen with age (p &lt; 0.001), septic condition at admission (p &lt; 0.001), hemodynamic instability (p &lt; 0.001), low blood pressure (p &lt; 0.001), and abdominal affection (p &lt; 0.001). In laboratory findings, an increase of creatine kinase (p &lt; 0.001) and lactate (p &lt; 0.001) and a decrease of antithrombin III (p &lt; 0.007) and the Quick value (p &lt; 0.01) proved to be significant. Conclusion: Patients with Fournier\u2019s gangrene do not differ in all aspects from those with other NSTI. Successful treatment consists of immediate surgical debridement, broad-spectrum antibiotic treatment, and critical care management. Supportive hyperbaric oxygen therapy should be considered.<\/jats:p>","DOI":"10.1159\/000339161","type":"journal-article","created":{"date-parts":[[2012,7,3]],"date-time":"2012-07-03T15:29:34Z","timestamp":1341329374000},"page":"173-179","source":"Crossref","is-referenced-by-count":78,"title":["Prognostic Aspects, Survival Rate, and Predisposing Risk Factors in Patients with Fournier\u2019s Gangrene and Necrotizing Soft Tissue Infections: Evaluation of Clinical Outcome of 55 Patients"],"prefix":"10.1159","volume":"89","author":[{"given":"A.","family":"Martinschek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Evers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Lampl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Gerngro\u00df","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Sparwasser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,7,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097%2FMCC.0b013e32825a6a1b"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097%2F00000658-199505000-00013"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001%2Farchsurg.1924.01120080083007"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007%2Fs001040051287"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007%2Fs15010-008-8169-x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-0029-1242433"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.101.6.1481"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2168.2000.01497.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00268-005-0777-3"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9610%2801%2900785-1"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1086%2F511638"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1080%2F11024150260284897"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1017%2FS0950268806007448"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1468-3083.2006.01487.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097%2F00005373-198105000-00003"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.juro.2009.08.050"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097%2F00005392-199709000-00039"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2FS0090-4295%2800%2900604-X"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2F0002-9610%2894%2990240-2"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007%2Fs001010050558"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ju.0000158129.56571.05"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1089%2Fsur.2007.085"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1097%2F01.CCM.0000129486.35458.7D"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/uin\/article-pdf\/89\/2\/173\/3904574\/000339161.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/uin\/article-pdf\/89\/2\/173\/3904574\/000339161.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:26:18Z","timestamp":1745432778000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000339161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":23,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,9,1]]},"published-print":{"date-parts":[[2012,9,5]]}},"URL":"https:\/\/doi.org\/10.1159\/000339161","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"value":"0042-1138","type":"print"},{"value":"1423-0399","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}