{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T03:35:45Z","timestamp":1778556945374,"version":"3.51.4"},"reference-count":21,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T00:00:00Z","timestamp":1340841600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"},{"start":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T00:00:00Z","timestamp":1340841600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Extra"],"abstract":"<b><i>Background\/Aims:<\/i><\/b> Leaves of <i>Echinodorus macrophyllus<\/i> (EM), from the Alismataceae family, have been used in Brazilian folk medicine for their anti-inflammatory and diuretic properties. In this work, the diuretic and nephroprotective activities of crude extracts of EM were evaluated. <b><i>Methods: <\/i><\/b>Normal Wistar rats were given 0.9% NaCl containing either EM (10\u2013300 mg\/kg), furosemide (13 mg\/kg) or arginine vasopressin (0.2 mg\/kg). Thereafter, the rats were individually housed in metabolic cages, and urine volume was measured every 30 min for a total of 3 h. Acute kidney injury was induced by gentamicin (GM, 80 mg\u00b7kg<sup>\u20131<\/sup>\u00b7day<sup>\u20131<\/sup>, b.i.d., 5 days). Along with GM, 0.9% NaCl (control) or EM (30 mg\/kg) was given to the rats by gavage. <b><i>Results:<\/i><\/b> EM produced a dose-dependent reduction in urine elimination. EM was effective in reversing all GM-induced alterations such as polyuria and glomerular filtration rate reduction. The GM-induced morphological alterations were not observed when EM was given concomitantly with GM. <b><i>Conclusion:<\/i><\/b> This study provides evidence that EM possesses nephroprotective effect which indicates that EM may have therapeutic applications in GM-induced acute kidney injury.<\/jats:p>","DOI":"10.1159\/000339181","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T16:22:18Z","timestamp":1340814138000},"page":"177-183","source":"Crossref","is-referenced-by-count":14,"title":["Nephroprotective Effect of Echinodorus macrophyllus Micheli on Gentamicin-Induced Nephrotoxicity in Rats"],"prefix":"10.1159","volume":"2","author":[{"given":"Viviane Gomes","family":"Portella","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo Pereira","family":"Cosenza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00facio Ricardo Leite","family":"Diniz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00edlian Fernanda","family":"Pacheco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni Dantas","family":"Cassali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo Vidigal","family":"Caliari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria das Gra\u00e7as Lins","family":"Brand\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Aparecida Ribeiro","family":"Vieira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,6,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097%2FCCM.0b013e3181bfb0b5"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038%2Fnrneph.2011.14"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1128%2FAAC.01430-08"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.294.7.813"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0278-6915%2803%2900186-8"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfl699"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093%2Fqjmed%2Fhcp143"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.phymed.2003.11.010"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jep.2008.04.025"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.phrs.2008.12.009"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jep.2009.10.015"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jep.2006.11.022"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1556%2FABiol.54.2003.3-4.13"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2174%2F157488607781668891"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159%2F000185726"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.2010.337"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2FS0891-5849%2800%2900354-3"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1080%2F03009730903174321"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002%2Fptr.2861"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1248%2Fbpb.32.61"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1590%2FS0100-879X2003001200002"}],"container-title":["Nephron Extra"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/339181","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/339181","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/339181","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:26:25Z","timestamp":1745432785000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000339181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,28]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2012,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000339181","archive":["Portico"],"relation":{},"ISSN":["1664-5529"],"issn-type":[{"value":"1664-5529","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,28]]}}}