{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T01:22:32Z","timestamp":1772241752813,"version":"3.50.1"},"reference-count":25,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cytologica"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; Although Warthin\u2019s tumor (WT) is one of a few salivary gland tumors that have distinct cytologic findings, it can be confused with malignant tumors at times. We assessed the overall accuracy, unusual features, and diagnostic points of fine-needle aspiration (FNA) of WT. &lt;b&gt;&lt;i&gt;Study Design:&lt;\/i&gt;&lt;\/b&gt; We retrospectively collected histologically confirmed WT from 21 patients and reviewed preoperative FNA slides. Smears were subject to immunocytochemical staining for carcinoembryonic antigen (CEA) and c-kit and compared to metastatic squamous cell carcinoma. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; All of the cases were in the parotid gland; the mean size was 3.6 \u00b1 1.2 cm. Of 21 patients, 19 were male (age 59.7 \u00b1 9.4 years) and had a history of smoking. The initial FNA diagnoses were WT (11 patients, 52.4%), benign lesion (7 patients, 33.3%), and malignant neoplasm (3 patients, 14.3%). Only 6 patients (28.6%) showed typical FNA features of WT. The dominant cell types in the smears were macrophages (76.2%), squamous-like cells (66.7%), oncocytes (61.9%), and lymphoid cells (57.1%). Some showed atypical degenerated features, a necrotic background, and inflammatory cells, leading to misdiagnosis. CEA positivity and c-kit positivity in WT were noted in 0 and 75.0% of cases, respectively, whereas metastatic squamous cell carcinoma showed positive rates of 16.7 and 0%, respectively. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Awareness of potential sources of misdiagnosis together with combination of c-kit\/CEA immunostaining may result in an increased diagnostic rate of WT in FNA.<\/jats:p>","DOI":"10.1159\/000339195","type":"journal-article","created":{"date-parts":[[2012,9,27]],"date-time":"2012-09-27T00:35:42Z","timestamp":1348706142000},"page":"474-480","source":"Crossref","is-referenced-by-count":9,"title":["Fine-Needle Aspiration Cytology with c-kit Immunocytochemical Staining in the Diagnosis of Warthin\u2019s Tumor"],"prefix":"10.1159","volume":"56","author":[{"given":"Jung Yeon","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Sam","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Eun","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun-Jung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyeongmee","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,9,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002%2Fhed.21382"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.4081%2Fejh.2011.e20"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097%2FPAI.0b013e31820d2872"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002%2Fdc.21599"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.humpath.2011.05.003"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.humpath.2011.01.022"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097%2FIGC.0b013e31821a2567"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jdermsci.2011.02.011"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2559.2011.03753.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097%2FIGC.0b013e3182055c94"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.humpath.2010.09.002"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00534-010-0365-2"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2303.2009.00667.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159%2F000326975"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0339%28199703%2916%3A3%3C221%3A%3AAID-DC5%3E3.0.CO%3B2-I"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncr.11207"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2303.2002.00415.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159%2F000326508"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0339%28199803%2918%3A3%3C174%3A%3AAID-DC2%3E3.0.CO%3B2-E"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2559.2011.04058.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0339%28199708%2917%3A2%3C92%3A%3AAID-DC3%3E3.0.CO%3B2-Q"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0339%28199711%2917%3A5%3C347%3A%3AAID-DC7%3E3.0.CO%3B2-7"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2168.1999.01282.x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0339%28199709%2917%3A3%3C230%3A%3AAID-DC12%3E3.0.CO%3B2-G"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.2310%2F7070.2002.34289"}],"container-title":["Acta Cytologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/339195","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/339195","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:26:26Z","timestamp":1745432786000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000339195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":25,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2012,10,1]]},"published-print":{"date-parts":[[2012,10,12]]}},"URL":"https:\/\/doi.org\/10.1159\/000339195","archive":["Portico"],"relation":{},"ISSN":["0001-5547","1938-2650"],"issn-type":[{"value":"0001-5547","type":"print"},{"value":"1938-2650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}