{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:34:14Z","timestamp":1745469254776,"version":"3.40.4"},"reference-count":19,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2012]]},"abstract":"<b><i>Background:<\/i><\/b> High-dose recombinant human erythropoietin (rEpo) has first been administered in clinical trials for neuroprotection in very preterm neonates at high risk of brain injury and in (near-) term neonates with hypoxic-ischemic encephalopathy. However, recent trials in adults raised concerns about the safety of high-dose rEpo for neuro- and cardioprotection. <b><i>Objectives:<\/i><\/b> To evaluate the putative accumulation or renal leakage of Epo as a function of developmental stage after repetitive early short-term infusion of high-dose rEpo (3 \u00d7 3,000 U\/kg within 42 h after birth; NCT00413946) for neuroprotection in very preterm infants. <b><i>Methods:<\/i><\/b> Epo concentrations were measured using the ELISA technique in the first two consecutive urine specimens after each rEpo infusion. <b><i>Results:<\/i><\/b> Renal Epo excretion was significantly higher in preterm infants with gestational ages <29 weeks than in more mature infants and reached up to 23% of the administered rEpo within 8 h after each infusion. The urinary Epo concentration did not increase after three repetitive infusions of high-dose rEpo. The ratio of urinary Epo to total protein concentrations was the same in infants with gestational ages <29 weeks and in those with gestational ages \u226529 weeks. <b><i>Conclusions:<\/i><\/b> Our data suggest that the higher renal Epo excretion in more immature infants may be attributed to a higher glomerular filtration leakage due to the lower maturation of the kidneys and argue against saturation kinetics after multiple doses of 3,000 U\/kg rEpo. This information should be considered in future trials on the use of rEpo for neuroprotection in neonates.<\/jats:p>","DOI":"10.1159\/000339283","type":"journal-article","created":{"date-parts":[[2012,7,5]],"date-time":"2012-07-05T02:30:40Z","timestamp":1341455440000},"page":"172-177","source":"Crossref","is-referenced-by-count":3,"title":["Urinary Erythropoietin Concentrations after Early Short-Term Infusion of High-Dose Recombinant Epo for Neuroprotection in Preterm Neonates"],"prefix":"10.1159","volume":"102","author":[{"given":"Christof","family":"Dame","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliane","family":"Langer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte M.","family":"Koller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Claude","family":"Fauch\u00e8re","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans Ulrich","family":"Bucher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,7,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2007-2591"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2007-2711"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2008-3553"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2009-2268"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1161%2FSTROKEAHA.109.564872"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa0907845"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa062276"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2809%2960502-X"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMp0912328"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.2010.187344"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaapos.2005.09.005"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.104.6.e76"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2009-1426"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159%2F000153094"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2125.1996.41911.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jpeds.2008.01.026"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1651-2227.1997.tb14802.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2008-2942"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.resuscitation.2007.10.003"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/339283","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/339283","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:27:30Z","timestamp":1745432850000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000339283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":19,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,9,1]]},"published-print":{"date-parts":[[2012,9,24]]}},"URL":"https:\/\/doi.org\/10.1159\/000339283","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"type":"print","value":"1661-7800"},{"type":"electronic","value":"1661-7819"}],"subject":[],"published":{"date-parts":[[2012]]}}}