{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:06:05Z","timestamp":1789193165569,"version":"build-2803163510"},"reference-count":14,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; The combination of systemic pulse corticosteroids and methotrexate in the treatment of severe alopecia areata has never been reported. &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; The objective of this work was to give arguments for the efficacy and safety of this combined treatment. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; This was a retrospective case series of patients treated with intravenous 500 mg methylprednisolone per day for 3 consecutive days monthly during 3 months plus methotrexate initiated at the end of the second pulse regimen. We reviewed all case notes of patients who received this regimen between January 1 2007 and December 1 2010. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Twenty patients were treated. Data on hair regrowth at month 12 were available for all patients; 14 patients were still receiving the treatment on December 1 2010, 2 patients were lost of follow-up, and 4 patients had stopped the treatment. Of the 14 patients who were still receiving the treatment regimen at month 18, 10 (10\/20, 50%) had total hair regrowth and 4 (4\/20, 20%) had incomplete but satisfactory hair regrowth. The treatment was well tolerated. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; The initial treatment by pulse intravenous corticosteroids may influence the overall response. This approach should be evaluated in a larger series of patients.<\/jats:p>","DOI":"10.1159\/000339341","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T13:30:45Z","timestamp":1340803845000},"page":"369-373","source":"Crossref","is-referenced-by-count":39,"title":["Interest of High-Dose Pulse Corticosteroid Therapy Combined with Methotrexate for Severe Alopecia Areata: A Retrospective Case Series"],"prefix":"10.1159","volume":"224","author":[{"given":"Catherine","family":"Droitcourt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Milpied","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Ezzedine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Hubiche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Belin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Akpadjan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Ta\u00efeb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Seneschal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2012,6,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038%2Fnature09114"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.331.7522.951"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.2340%2F00015555-1031"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2009.10.031"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159%2F000107626"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159%2F000247268"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0190-9622%2898%2970009-X"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2008.08458.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0151-9638%2804%2993596-X"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2005.09.010"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.annder.2010.06.031"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159%2F000092287"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2006.05.008"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2011.10383.x"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/339341","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/339341","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:28:04Z","timestamp":1745432884000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000339341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":14,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2012,8,1]]},"published-print":{"date-parts":[[2012,8,2]]}},"URL":"https:\/\/doi.org\/10.1159\/000339341","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}