{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T19:16:56Z","timestamp":1771010216841,"version":"3.50.1"},"reference-count":24,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; To investigate whether preprocedural high-dose atorvastatin decreases the incidence of contrast-induced nephropathy (CIN) and protects the renal function after emergency percutaneous coronary intervention (PCI). &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Statin-naive patients with acute ST-segment elevation myocardial infarction (STEMI) undergoing emergency PCI (n = 161) randomly received atorvastatin (80 mg, n = 78, ATOR group) or placebo [n = 83, control (CON) group] followed by long-term atorvastatin (40 mg\/day). The primary end point was incidence of CIN. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; In the ATOR group, 2.6% of the patients developed CIN versus 15.7% in the CON group (p = 0.01). In the ATOR group, postprocedural serum creatinine was significantly lower (93.4 \u00b1 17.1 vs. 112.6 \u00b1 23.3 \u00b5mol\/l at 48 h and 84.2 \u00b1 14.2 vs. 95.3 \u00b1 17.7 \u00b5mol\/l at 72 h, both p &lt; 0.0001) and in the CON group, peak serum cystatin C was lower (0.51 \u00b1 0.14 vs. 0.61 \u00b1 0.13 mg\/l, p &lt; 0.0001). Atorvastatin pretreatment was independently associated with a decreased risk of CIN (OR 0.084, 95% CI 0.015\u20130.462, p = 0.004). The proportion of alanine aminotransferase &gt;3 \u00d7 upper limit of the normal value within 1 month was 3.85 versus 1.20% (ATOR vs. CON group, p = 0.57). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Preprocedural high-dose atorvastatin prevents CIN and protects the renal function in patients with acute STEMI undergoing emergency PCI.<\/jats:p>","DOI":"10.1159\/000339472","type":"journal-article","created":{"date-parts":[[2012,7,31]],"date-time":"2012-07-31T06:49:25Z","timestamp":1343717365000},"page":"195-202","source":"Crossref","is-referenced-by-count":49,"title":["Beneficial Effects of High-Dose Atorvastatin Pretreatment on Renal Function in Patients with Acute ST-Segment Elevation Myocardial Infarction Undergoing Emergency Percutaneous Coronary Intervention"],"prefix":"10.1159","volume":"122","author":[{"given":"Wei","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianghua","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanbo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangnan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zengxin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuechao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Geng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinshun","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guozhen","family":"Hao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunfa","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weize","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weili","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiqiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,7,31]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.amjcard.2009.10.044"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cjca.2011.05.005"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ijcard.2007.05.004"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jacc.2006.06.061"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1161%2FCIRCULATIONAHA.106.621763"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.amjcard.2011.03.001"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000137828.06205.87"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jacc.2007.02.025"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jacc.2009.05.028"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1503%2Fcmaj.1040847"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ijcard.2011.06.115"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jacc.2008.10.061"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3109%2F02841851.2010.486804"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1161%2FCIRCULATIONAHA.109.902189"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jacc.2009.08.091"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.amjcard.2011.01.045"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.amjmed.2005.03.031"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ijcard.2007.01.123"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jjcc.2009.05.006"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1440-1797.2009.01204.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097%2FMBC.0b013e32833a901c"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1177%2F0003319710364216"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ahj.2007.11.042"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.amjcard.2009.09.026"}],"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/339472","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/339472","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/339472","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:29:26Z","timestamp":1745432966000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000339472"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":24,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,8,1]]},"published-print":{"date-parts":[[2012,8,16]]}},"URL":"https:\/\/doi.org\/10.1159\/000339472","archive":["Portico"],"relation":{},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"value":"0008-6312","type":"print"},{"value":"1421-9751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}