{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T14:48:53Z","timestamp":1769006933819,"version":"3.49.0"},"reference-count":37,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; To examine aortic systolic blood pressure (SBP&lt;sub&gt;Ao&lt;\/sub&gt;), pulse wave velocity (PWV) and augmentation index (adjusted to a heart rate of 75 beats per minute, AIx-75) at 11\u201313 weeks\u2019 gestation in pregnancies delivering small for gestational age (SGA) neonates with and without preeclampsia (PE). &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; At 11+0 to 13+6 weeks\u2019 gestation, maternal history was recorded and PWV, AIx-75, SBP&lt;sub&gt;Ao&lt;\/sub&gt;, uterine artery pulsatility index (PI) and maternal serum pregnancy-associated plasma protein-A (PAPP-A) were measured. We compared women with (n = 337) and without (n = 48) PE that delivered SGA neonates with unaffected controls (n = 6,429). &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; In the SGA group without PE, compared to unaffected controls, there was no significant difference in AIx-75 (1.03 vs. 1.00 multiple of the median, MoM), PWV (0.98 vs. 1.00 MoM) or SBP&lt;sub&gt;Ao&lt;\/sub&gt; (1.01 vs. 1.00 MoM), but uterine artery PI was increased (1.10 vs. 1.00 MoM) and PAPP-A decreased (0.85 vs. 1.00 MoM). In SGA with PE, compared to unaffected controls, there was increased AIx-75 (1.13 vs. 1.00 MoM), SBP&lt;sub&gt;Ao&lt;\/sub&gt; (1.09 vs. 1.00 MoM), uterine artery PI (1.40 vs. 1.00 MoM) and decreased PAPP-A (0.72 vs. 1.00 MoM), but no significant difference in PWV (1.05 vs. 1.00 MoM). &lt;b&gt;&lt;i&gt;Conclusion: &lt;\/i&gt;&lt;\/b&gt;In pregnancies with SGA neonates, impaired placentation is reflected in low PAPP-A and high uterine artery PI at 11\u201313 weeks\u2019 gestation. In the SGA group with PE, but not in those without PE, there is increased SBP&lt;sub&gt;Ao&lt;\/sub&gt; and AIx-75.<\/jats:p>","DOI":"10.1159\/000339480","type":"journal-article","created":{"date-parts":[[2012,9,25]],"date-time":"2012-09-25T17:51:39Z","timestamp":1348595499000},"page":"231-238","source":"Crossref","is-referenced-by-count":25,"title":["Maternal Hemodynamics at 11\u201313 Weeks of Gestation in Pregnancies Delivering Small for Gestational Age Neonates"],"prefix":"10.1159","volume":"32","author":[{"given":"A.","family":"Khalil","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Sodre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Syngelaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Akolekar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.H.","family":"Nicolaides","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,9,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199904223401603"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.111.1.e61"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002%2Fuog.5252"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1095%2Fbiolreprod.102.014977"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2Fpd.2660"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159%2F000321694"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.323.7323.1213"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2800%2905112-6"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2805%2967726-4"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.39335.385301.BE"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1291%2Fhypres.31.1135"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1161%2FHYPERTENSIONAHA.107.089078"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093%2Feurheartj%2Fehl254"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.amjhyper.2004.05.018"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1471-0528.2005.00701.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1161%2FHYPERTENSIONAHA.109.130898"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1152%2Fajpheart.01106.2008"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1471-0528.2008.01906.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002%2Fuog.11183"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002%2Fuog.5332"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002%2Fuog.5157"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002%2Fpd.2520"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9378%2899%2970239-5"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1161%2F01.HYP.38.3.718"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1161%2Fhq0102.101770"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.amjhyper.2003.10.009"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.2147%2Fvhrm.2006.2.1.19"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1159%2F000324320"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1097%2FHJH.0b013e3283432063"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1161%2FCIRCULATIONAHA.105.579342"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1253%2Fcircj.69.259"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1161%2FCIRCULATIONAHA.105.555235"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1161%2Fhq1201.100226"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.320.7238.839"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2800%2903406-1"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2800%2905112-6"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1161%2FCIRCULATIONAHA.111.034884"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/339480","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/339480","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:29:29Z","timestamp":1745432969000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000339480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":37,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2012,12,1]]},"published-print":{"date-parts":[[2012,12,5]]}},"URL":"https:\/\/doi.org\/10.1159\/000339480","archive":["Portico"],"relation":{},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"value":"1015-3837","type":"print"},{"value":"1421-9964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}