{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T13:59:56Z","timestamp":1778075996039,"version":"3.51.4"},"reference-count":16,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; The utility of amplitude-integrated electroencephalography (aEEG) monitoring has been established for patients with neonatal hypoxic-ischemic encephalopathy. &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; To evaluate the role of aEEG in the diagnostic process and treatment of patients with encephalopathy due to inborn errors of metabolism. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Cases collected through an international registry were divided into 5 groups of metabolic disorders. Common aEEG features were sought for each group. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; In total, 21\/30 (70%) cases had abnormal aEEG background patterns, 18\/30 (60%) showed seizure activity. Patients with disorders of energy metabolism, hyperammonemia, and organic\/amino acidopathies often showed marked aEEG depression with seizure activity. In contrast, aEEGs of patients with peroxisomal disorders did not show major background abnormalities but seizures were present in 5\/6 subjects. We report two features of interest: firstly, two tracings displayed an unusual upward shift of the lower aEEG amplitude margin. Secondly, aEEGs of infants with non-ketotic hyperglycinemia showed a pattern we refer to as \u2018high-frequency burst-suppression pattern\u2019. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; aEEG in patients with inborn errors of metabolism frequently reveals abnormalities and assists clinicians in the clinical assessment, management and monitoring of these patients.<\/jats:p>","DOI":"10.1159\/000339567","type":"journal-article","created":{"date-parts":[[2012,7,13]],"date-time":"2012-07-13T15:29:28Z","timestamp":1342193368000},"page":"203-211","source":"Crossref","is-referenced-by-count":28,"title":["Amplitude-Integrated Electroencephalography in Newborns with Inborn Errors of Metabolism"],"prefix":"10.1159","volume":"102","author":[{"given":"Monika","family":"Olischar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eilon","family":"Shany","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Canan","family":"Ayg\u00fcn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis","family":"Azzopardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rod W.","family":"Hunt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona C.","family":"Toet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ada","family":"Hamosh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda S.","family":"de Vries","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lena","family":"Hellstr\u00f6m-Westas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiane","family":"Theda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,7,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1053%2Fsiny.2001.0083"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.102.6.e69"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10545-009-1045-8"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10545-009-1171-3"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1203%2F01.pdr.0000127019.52562.8c"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.2004.064964"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.clp.2008.07.017"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2800%2905269-7"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.4.5682.545-a"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.siny.2006.07.011"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1528-1157.1971.tb03920.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0370-4475%2878%2980125-7"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038%2F338422a0"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.2005.086314"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2007-1839"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2009-0136"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/339567","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/339567","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:30:11Z","timestamp":1745433011000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000339567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":16,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,9,1]]},"published-print":{"date-parts":[[2012,9,24]]}},"URL":"https:\/\/doi.org\/10.1159\/000339567","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}