{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T10:51:53Z","timestamp":1778755913124,"version":"3.51.4"},"reference-count":15,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Stereotact Funct Neurosurg"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Radiation-induced meningiomas present a unique clinical dilemma given the fact that patients with these tumors have often received a prior full course of radiotherapy. As such, traditional radiotherapy is limited by lifetime tissue tolerances to radiation, leaving surgery and radiosurgery as attractive treatment options. &lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; To ascertain the safety and efficacy of Gamma Knife radiosurgery as a treatment for radiation-induced meningiomas. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; A retrospective chart review was conducted to identify patients who received Gamma Knife radiosurgery for a meningioma and met the criteria for this being a radiation-induced tumor. Serial imaging was used to determine the outcome of treatment and clinical notes used to assess for toxicity. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; We present our series of 12 patients with radiation-induced meningiomas treated with Gamma Knife stereotactic radiosurgery over a 12-year period at our institution. With a median follow-up of 35 months, local control was 100%. Two patients experienced distant brain failure (&gt;2 cm from previous radiosurgical volume). Two patients experienced posttreatment toxicity related to treatment-related edema. A review of data collected from the scientific literature suggests that tumor volume predicts for treatment failure of radiosurgery. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Gamma Knife radiosurgery is both a safe and effective treatment for radiation-induced meningiomas.<\/jats:p>","DOI":"10.1159\/000339636","type":"journal-article","created":{"date-parts":[[2012,8,23]],"date-time":"2012-08-23T09:19:52Z","timestamp":1345713592000},"page":"365-369","source":"Crossref","is-referenced-by-count":16,"title":["Gamma Knife Stereotactic Radiosurgery for Radiation-Induced Meningiomas"],"prefix":"10.1159","volume":"90","author":[{"given":"Elizabeth N.","family":"Kuhn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen B.","family":"Tatter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas L.","family":"Ellis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,8,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0936-6555%2805%2980187-6"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3171%2Fjns.1990.73.4.0502"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3171%2Fjns.1991.75.4.0564"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1215%2F15228517-2008-122"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2Fpbc.21153"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM198810203191601"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3171%2Fjns.2004.100.6.1002"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0360-3016%2800%2900609-X"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1227%2F01.NEU.0000336765.85922.D9"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ijrobp.2004.09.033"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0142%2819980101%2982%3A1%3C8%3A%3AAID-CNCR3%3E3.0.CO%3B2-W"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ijrobp.2009.10.045"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136%2Fbjo.37.12.758"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3171%2FJNS-07%2F08%2F0325"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11060-012-0828-1"}],"container-title":["Stereotactic and Functional Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/339636","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/339636","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:31:06Z","timestamp":1745433066000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000339636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":15,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2012,12,1]]},"published-print":{"date-parts":[[2012,12,4]]}},"URL":"https:\/\/doi.org\/10.1159\/000339636","archive":["Portico"],"relation":{},"ISSN":["1011-6125","1423-0372"],"issn-type":[{"value":"1011-6125","type":"print"},{"value":"1423-0372","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}