{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T10:52:25Z","timestamp":1753440745448,"version":"3.40.4"},"reference-count":15,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2012,7,25]],"date-time":"2012-07-25T00:00:00Z","timestamp":1343174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,7,25]],"date-time":"2012-07-25T00:00:00Z","timestamp":1343174400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>The detection of testosterone-producing ovarian tumors in childhood and adolescence by imaging techniques only can be difficult because of the tumors' radiological structure and sometimes diminutive size. We describe an 11.5-year-old girl with a 9-month history of voice deepening, mild hirsutism, minor acne, increased growth velocity, weight gain, and clit-oromegaly. Laboratory investigation revealed an extremely elevated serum testosterone level without any additional endocrine abnormalities. Abdominal ultrasound and MRI showed a sparsely noticeable solid mass in the center of the right ovary. At laparotomy, blood was selectively drawn from the right and the left ovarian veins. Rapid testosterone measurement revealed a 70-fold higher testosterone concentration in the right ovarian vein within 45 min. Based on this finding, a right salpingo-oophorectomy was performed. The patient's postoperative testosterone level declined within 24 h. The histopathological diagnosis was Leydig cell tumor. In conclusion, the implementation of a fast intraoperative testosterone assay enabled the localization and curative therapy of a Leydig cell tumor. This technique seems to be a good alternative to preoperative selective venous blood sampling when body imaging does not unveil the tumor's site.<\/jats:p>","DOI":"10.1159\/000339683","type":"journal-article","created":{"date-parts":[[2012,7,25]],"date-time":"2012-07-25T08:20:05Z","timestamp":1343204405000},"page":"110-113","source":"Crossref","is-referenced-by-count":3,"title":["Fast Intraoperative Testosterone Assay Confirms the Location of an Ovarian Virilizing Tumor in a Young Girl"],"prefix":"10.1159","volume":"79","author":[{"given":"R.","family":"Braun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Peter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Warmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Fuchs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Binder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,7,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s004040000114"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1080\/09513590801953465"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1210\/jc.87.7.3074"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2003.030817"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1080\/09513590500369005"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22918"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-011-0186-6"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2000.00123.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2007.092080"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9120(00)00141-7"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2004.12.055"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-020374"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2007.11.008"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/BF02577904"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2008.03389.x"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/339683","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/339683","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:31:19Z","timestamp":1745433079000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000339683"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,25]]},"references-count":15,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,3,1]]},"published-print":{"date-parts":[[2013,3,15]]}},"URL":"https:\/\/doi.org\/10.1159\/000339683","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"type":"print","value":"1663-2818"},{"type":"electronic","value":"1663-2826"}],"subject":[],"published":{"date-parts":[[2012,7,25]]}}}