{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:29:19Z","timestamp":1762079359142,"version":"3.40.4"},"reference-count":20,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2012,8,8]],"date-time":"2012-08-08T00:00:00Z","timestamp":1344384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"},{"start":{"date-parts":[[2012,8,8]],"date-time":"2012-08-08T00:00:00Z","timestamp":1344384000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord Extra"],"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background\/Aims:&lt;\/i&gt;&lt;\/b&gt; Large clinical trials including patients with uncommon diseases involve assessors in different geographical locations, resulting in considerable inter-rater variability in assessment scores. As video recordings of examinations, which can be individually rated, may eliminate such variability, we measured the agreement between a single video rater and multiple examining physicians in the context of PRION-1, a clinical trial of the antimalarial drug quinacrine in human prion diseases. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We analysed a 43-component neurocognitive assessment battery, on 101 patients with Creutzfeldt-Jakob disease, focusing on the correlation and agreement between examining physicians and a single video rater. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; In total, 335 videos of examinations of 101 patients who were video-recorded over the 4-year trial period were assessed. For neurocognitive examination, inter-observer concordance was generally excellent. Highly visual neurological examination domains (e.g. finger-nose-finger assessment of ataxia) had good inter-rater correlation, whereas those dependent on non-visual clues (e.g. power or reflexes) correlated poorly. Some non-visual neurological domains were surprisingly concordant, such as limb muscle tone. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Cognitive assessments and selected neurological domains can be practically and accurately recorded in a clinical trial using video rating. Video recording of examinations is a valuable addition to any trial provided appropriate selection of assessment instruments is used and rigorous training of assessors is undertaken.<\/jats:p>","DOI":"10.1159\/000339730","type":"journal-article","created":{"date-parts":[[2012,8,8]],"date-time":"2012-08-08T05:40:20Z","timestamp":1344404420000},"page":"286-297","source":"Crossref","is-referenced-by-count":7,"title":["Video Rating in Neurodegenerative Disease Clinical Trials: The Experience of PRION-1"],"prefix":"10.1159","volume":"2","author":[{"given":"Christopher","family":"Carswell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Ra\u00f1opa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suvankar","family":"Pal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"MacFarlane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Durre","family":"Siddique","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dafydd","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Webb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Wroe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Walker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet","family":"Darbyshire","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Collinge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Mead","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Rudge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,8,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1212%2FWNL.0b013e3181c67808"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneurol.2009.334"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.2009.1866"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2808%2961074-0"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1212%2FWNL.0b013e3181d6476a"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2804%2916499-4"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1161%2FSTROKEAHA.108.515262"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.gaitpost.2007.08.008"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1146%2Fannurev.neuro.24.1.519"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1212%2F01.wnl.0000308955.25760.c2"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS1474-4422%2809%2970049-3"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.161274798"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.61.9.1416"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000091847.82140.9D"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002%2Fmds.22127"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1212%2FWNL.58.3.433"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1212%2F01.WNL.0000094355.51119.D2"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159%2F000090296"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.2307%2F2529310"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2886%2990837-8"}],"container-title":["Dementia and Geriatric Cognitive Disorders Extra"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/339730","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/339730","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:32:07Z","timestamp":1745433127000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000339730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,8]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2012,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000339730","archive":["Portico"],"relation":{},"ISSN":["1664-5464"],"issn-type":[{"type":"electronic","value":"1664-5464"}],"subject":[],"published":{"date-parts":[[2012,8,8]]}}}