{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:27:06Z","timestamp":1758817626501,"version":"3.40.4"},"reference-count":39,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>The pathogenesis of hidradenitis suppurativa (HS) is still enigmatic, and a valid animal model for HS is currently not available. The recent discovery of \u03b3-secretase mutations in a subpopulation of patients with HS suggested \u03b3-secretase transgenic mice as a model for HS pathogenesis. However, the discrepancies between human HS and these mice are daunting. We critically review cases of animal HS and transgenic \u03b3-secretase mouse models for HS and discuss the criteria which should be met for a representative pathogenic model.<\/jats:p>","DOI":"10.1159\/000339773","type":"journal-article","created":{"date-parts":[[2012,8,14]],"date-time":"2012-08-14T10:16:52Z","timestamp":1344939412000},"page":"9-13","source":"Crossref","is-referenced-by-count":16,"title":["Can Animal Skin Diseases or Current Transgenic Mice Serve as a Model for Hidradenitis Suppurativa?"],"prefix":"10.1159","volume":"225","author":[{"given":"H.H.","family":"van der 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