{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:32:49Z","timestamp":1788305569972,"version":"build-2803163510"},"reference-count":53,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2012,9,25]],"date-time":"2012-09-25T00:00:00Z","timestamp":1348531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,9,25]],"date-time":"2012-09-25T00:00:00Z","timestamp":1348531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Selective IgA deficiency (SIgAD) is the most common primary immunodeficiency disorder, which is characterized by significantly decreased serum levels of IgA. Abnormalities of CD4+CD25&lt;sup&gt;high&lt;\/sup&gt;forkhead box P3 (FoxP3)+ regulatory T cells (T&lt;sub&gt;reg&lt;\/sub&gt;) have been shown in association with autoimmune and inflammatory disorders. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; In order to evaluate the relationship between autoimmunity and T&lt;sub&gt;reg&lt;\/sub&gt; in SIgAD, we studied 26 IgA-deficient patients (aged 4\u201317 years) with serum IgA levels &lt;7 mg\/dl, 26 age- and sex-matched healthy controls and 26 age- and sex matched idiopathic thrombocytopenic purpura cases with normal immune system. T&lt;sub&gt;reg&lt;\/sub&gt; were determined by flow cytometry using T&lt;sub&gt;reg&lt;\/sub&gt; markers, including CD4, CD25 and FoxP3. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The mean percentage of CD4, CD25+FoxP3+ T&lt;sub&gt;reg&lt;\/sub&gt; from all CD4+ cells was 4.08 \u00b1 0.86 in healthy controls, which was significantly higher than in SIgAD patients (2.93 \u00b1 1.3; p = 0.003). We set a cutoff point (2.36%) for T&lt;sub&gt;reg&lt;\/sub&gt;, which was two standard deviations lower than the mean of normal controls. According to this cutoff point and in order to assess the role of T&lt;sub&gt;reg&lt;\/sub&gt; in clinical SIgAD manifestation, we classified patients into two groups: 16 patients in G1 with T&lt;sub&gt;reg&lt;\/sub&gt; &lt;2.36% and 10 patients in G2 with T&lt;sub&gt;reg&lt;\/sub&gt; &gt;2.36%. Autoimmunity was recorded in 9 patients (53.3%) of G1 and only 1 patient of G2, respectively (p = 0.034). Although a defect in class switching recombination was observed in 40% of the patients in G1, none of the G2 patients had such a defect (p = 0.028). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; This study showed decreased proportions of T&lt;sub&gt;reg&lt;\/sub&gt; in SIgAD patients, particularly in those with signs of chronic inflammation.<\/jats:p>","DOI":"10.1159\/000339867","type":"journal-article","created":{"date-parts":[[2012,9,25]],"date-time":"2012-09-25T17:51:38Z","timestamp":1348595498000},"page":"208-214","source":"Crossref","is-referenced-by-count":29,"title":["Evaluation of Natural Regulatory T Cells in Subjects with Selective IgA Deficiency: From Senior Idea to Novel Opportunities"],"prefix":"10.1159","volume":"160","author":[{"given":"Habib","family":"Soheili","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Abolhassani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narges","family":"Arandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein 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