{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:05:24Z","timestamp":1773270324698,"version":"3.50.1"},"reference-count":15,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2012,10,18]],"date-time":"2012-10-18T00:00:00Z","timestamp":1350518400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,10,18]],"date-time":"2012-10-18T00:00:00Z","timestamp":1350518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2013]]},"abstract":"<b><i>Background:<\/i><\/b> Chronic urticaria (CU) may affect up to 1% of the general population. <i>Anisakis simplex<\/i> hypersensitivity is frequent in areas where raw fish is consumed and <i>A. simplex<\/i> allergy represents a relevant cause of acute urticaria. We assessed the possible association between CU and <i>A. simplex<\/i> sensitization in an area where marinated fish is very frequently eaten. <b><i>Methods:<\/i><\/b> A thorough history of CU was sought in 919 adults seen at the Allergy Center, Bari. CU patients and 187 controls underwent skin-prick testing with a commercial extract of <i>A. simplex<\/i>, and reactors were recommended a 6-month raw-fish-free diet regimen. Responders were followed after a further 3 months. <b><i>Results:<\/i><\/b> Of 919 subjects, 213 (23%) met the criteria for CU and 106\/213 (49.7%) were sensitized to <i>A. simplex<\/i> with a significant difference between patients aged >65 or <65 years (56 vs. 41%, respectively; p < 0.05). All patients hypersensitive to <i>A. simplex<\/i> were regular consumers of marinated fish. In a control population without CU, the prevalence of <i>A. simplex<\/i> sensitization was 16% (p < 0.001). The 6-month diet regimen led to the disappearance of urticaria in 82\/106 cases (77%) versus 1\/42 (2%) subjects who did not change their dietary habits (p < 0.001). All nonresponders were sensitized to house-dust mites. Of 75 responders who were followed-up after 3 months, CU relapsed in 88% of those who had reintroduced raw fish versus 14% of those who were still on the diet (p < 0.001). <b><i>Conclusion:<\/i><\/b> In areas where raw or marinated fish is frequently eaten, <i>A. simplex<\/i> hypersensitivity is a frequent cause of CU.<\/jats:p>","DOI":"10.1159\/000339869","type":"journal-article","created":{"date-parts":[[2012,10,19]],"date-time":"2012-10-19T15:40:51Z","timestamp":1350661251000},"page":"297-300","source":"Crossref","is-referenced-by-count":52,"title":["<b><i>Anisakis<\/i><\/b> <b><i>simplex<\/i><\/b> Hypersensitivity Is Associated with Chronic Urticaria in Endemic Areas"],"prefix":"10.1159","volume":"160","author":[{"given":"M.T.","family":"Ventura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Napolitano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Menga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Cecere","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Asero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,10,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1067%2Fmai.2000.105706"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199506293322608"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.iac.2004.01.003"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMcp011186"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.1997.tb02590.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097%2F01.all.0000168795.12701.fd"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1398-9995.2000.03405.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.2009.02179.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00403-010-1069-9"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097%2F01.all.0000168795.12701.fd"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1157%2F13070606"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.2011.02691.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.anai.2012.01.013"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1089%2Ffpd.2009.0484"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.aller.2009.09.004"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/339869","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/339869","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:33:19Z","timestamp":1745433199000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000339869"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,18]]},"references-count":15,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,2,1]]},"published-print":{"date-parts":[[2013,2,13]]}},"URL":"https:\/\/doi.org\/10.1159\/000339869","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,18]]}}}